The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression

The four mammalian Jak tyrosine kinases are non‐covalently associated with cell surface receptors binding helical bundled cytokines. In the type I interferon receptor, Tyk2 associates with the IFNAR1 receptor subunit and positively influences ligand binding to the receptor complex. Here, we report t...

Ausführliche Beschreibung