Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1

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Veröffentlicht in:	Molecular and Cellular Biology 2003-01, Vol.23 (1), p.389-401
Hauptverfasser:	Itahana, Koji, Zou, Ying, Itahana, Yoko, Martinez, Jose-Luis, Beausejour, Christian, Jacobs, Jacqueline J. L., van Lohuizen, Maarten, Band, Vimla, Campisi, Judith, Dimri, Goberdhan P.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES BASIC BIOLOGICAL SCIENCES Cell Division - genetics Cell Growth and Development Cells, Cultured Cellular Senescence - physiology Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism DNA Replication FIBROBLASTS Fibroblasts - cytology Fibroblasts - physiology Helix-Turn-Helix Motifs Humans LIFE SPAN Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Oxygen - metabolism Polycomb Repressive Complex 1 Polycomb-Group Proteins Protein Structure, Tertiary PROTEINS Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Repressor Proteins Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism Telomerase - genetics Telomerase - metabolism Telomere - genetics Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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