CRM1/Ran-Mediated Nuclear Export of p27Kip1 Involves a Nuclear Export Signal and Links p27 Export and Proteolysis

We show that p27 localization is cell cycle regulated and we suggest that active CRM1/RanGTP-mediated nuclear export of p27 may be linked to cytoplasmic p27 proteolysis in early G1. p27 is nuclear in G0 and early G1 and appears transiently in the cytoplasm at the G1/S transition. Association of p27...

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Veröffentlicht in:	Molecular biology of the cell 2003-01, Vol.14 (1), p.201-213
Hauptverfasser:	Connor, Michael K., Kotchetkov, Rouslan, Cariou, Sandrine, Resch, Ansgar, Lupetti, Rafaella, Beniston, Richard G., Melchior, Frauke, Hengst, Ludger, Slingerland, Joyce M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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