The influence of beta‐adrenoceptor antagonists with and without intrinsic sympathomimetic activity on local wall motion abnormalities in patients with coronary heart disease
1 A single‐blind randomized study of the effects of a beta‐adrenoceptor antagonist with intrinsic sympathomimetic activity (pindolol 0.4 mg i.v., n = 10) and a drug lacking this property (metoprolol 5 mg i.v., n = 11) on local wall motion abnormalities was carried out in 21 patients with coronary he...
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| Veröffentlicht in: | British journal of clinical pharmacology 1982-01, Vol.13 (S2), p.301S-304S |
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| container_issue | S2 |
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| container_title | British journal of clinical pharmacology |
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| creator | Gleichmann, U Fassbender, D Trieb, G Mannebach, H Ohlmeier, H |
| description | 1 A single‐blind randomized study of the effects of a beta‐adrenoceptor antagonist with intrinsic sympathomimetic activity (pindolol 0.4 mg i.v., n = 10) and a drug lacking this property (metoprolol 5 mg i.v., n = 11) on local wall motion abnormalities was carried out in 21 patients with coronary heart disease and anterior wall hypokinesia. 2 The drugs produced similar changes in left ventricular end diastolic pressure (LVEDP) and end diastolic volume index (EDVI) but differed in their effects on heart rate and ejection fraction. Pindolol did not exert any marked effect on heart rate or ejection fraction whereas after metoprolol treatment both were significantly decreased. 3 Shortening of the hypokinetic wall segments was improved by both drugs. Shortening of the non‐hypokinetic contralateral segments was unchanged after pindolol administration but was decreased after metoprolol. 4 The differing effects of beta‐adrenoceptor antagonists on regional wall motion appear to be dependent on the presence or absence of intrinsic sympathomimetic activity. |
| doi_str_mv | 10.1111/j.1365-2125.1982.tb01930.x |
| format | Article |
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Pindolol did not exert any marked effect on heart rate or ejection fraction whereas after metoprolol treatment both were significantly decreased. 3 Shortening of the hypokinetic wall segments was improved by both drugs. Shortening of the non‐hypokinetic contralateral segments was unchanged after pindolol administration but was decreased after metoprolol. 4 The differing effects of beta‐adrenoceptor antagonists on regional wall motion appear to be dependent on the presence or absence of intrinsic sympathomimetic activity.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.1982.tb01930.x</identifier><identifier>PMID: 6125180</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adrenergic beta-Antagonists - therapeutic use ; Adult ; Cardiac Catheterization ; Cineangiography ; Coronary Disease - drug therapy ; Coronary Disease - physiopathology ; Female ; Heart - physiopathology ; Heart Rate - drug effects ; Hemodynamics - drug effects ; Humans ; Male ; Metoprolol - therapeutic use ; Middle Aged ; Pindolol - therapeutic use ; Sympathomimetics - therapeutic use</subject><ispartof>British journal of clinical pharmacology, 1982-01, Vol.13 (S2), p.301S-304S</ispartof><rights>1982 The British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4770-a0cf8f1bde68fcfc7e8da05d8c3b6461addeecdf3bb88596a36f24f10b78e0e63</citedby><cites>FETCH-LOGICAL-c4770-a0cf8f1bde68fcfc7e8da05d8c3b6461addeecdf3bb88596a36f24f10b78e0e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6125180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gleichmann, U</creatorcontrib><creatorcontrib>Fassbender, D</creatorcontrib><creatorcontrib>Trieb, G</creatorcontrib><creatorcontrib>Mannebach, H</creatorcontrib><creatorcontrib>Ohlmeier, H</creatorcontrib><title>The influence of beta‐adrenoceptor antagonists with and without intrinsic sympathomimetic activity on local wall motion abnormalities in patients with coronary heart disease</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>1 A single‐blind randomized study of the effects of a beta‐adrenoceptor antagonist with intrinsic sympathomimetic activity (pindolol 0.4 mg i.v., n = 10) and a drug lacking this property (metoprolol 5 mg i.v., n = 11) on local wall motion abnormalities was carried out in 21 patients with coronary heart disease and anterior wall hypokinesia. 2 The drugs produced similar changes in left ventricular end diastolic pressure (LVEDP) and end diastolic volume index (EDVI) but differed in their effects on heart rate and ejection fraction. Pindolol did not exert any marked effect on heart rate or ejection fraction whereas after metoprolol treatment both were significantly decreased. 3 Shortening of the hypokinetic wall segments was improved by both drugs. Shortening of the non‐hypokinetic contralateral segments was unchanged after pindolol administration but was decreased after metoprolol. 4 The differing effects of beta‐adrenoceptor antagonists on regional wall motion appear to be dependent on the presence or absence of intrinsic sympathomimetic activity.</description><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Adult</subject><subject>Cardiac Catheterization</subject><subject>Cineangiography</subject><subject>Coronary Disease - drug therapy</subject><subject>Coronary Disease - physiopathology</subject><subject>Female</subject><subject>Heart - physiopathology</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Metoprolol - therapeutic use</subject><subject>Middle Aged</subject><subject>Pindolol - therapeutic use</subject><subject>Sympathomimetics - therapeutic use</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUcuOEzEQHCHQkl34BCSLA7cZ7PG8wgG0RLykleCwnK0eT3vjyGMH27PZ3PgE_mT_iS_BQ0IER3xxu6uruuTKsueMFiydl5uC8abOS1bWBVt2ZRF7ypacFncPssUJepgtKKdNXpc1e5ydh7ChlHHW1GfZWZNw1tFFdn-9RqKtMhNaicQp0mOEn99_wODROonb6DwBG-HGWR1iIDsd16kx_C7cFBM7em2DliTsxy2k5qhHjOkNMupbHffEWWKcBEN2YAwZXdSpA711fgSjo8aQVEjiarR_VkjnnQW_J2sEH8mgA0LAJ9kjBSbg0-N9kX19_-569TG_-vzh0-ryKpdV29IcqFSdYv2ATaekki12A9B66CTvm6phMAyIclC877uuXjbAG1VWitG-7ZBiwy-y1wfd7dSPOMjky4MRW6_H5Ek40OJfxOq1uHG3glW0TL-cBF4cBbz7NmGIYtRBojFg0U1BtBVtOV8u0-Crw6D0LgSP6rSEUTHHLTZizlTMmYo5bnGMW9wl8rO_bZ6ox3wT_uaA77TB_X8oi7erL3PFfwGEBMSx</recordid><startdate>19820101</startdate><enddate>19820101</enddate><creator>Gleichmann, U</creator><creator>Fassbender, D</creator><creator>Trieb, G</creator><creator>Mannebach, H</creator><creator>Ohlmeier, H</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19820101</creationdate><title>The influence of beta‐adrenoceptor antagonists with and without intrinsic sympathomimetic activity on local wall motion abnormalities in patients with coronary heart disease</title><author>Gleichmann, U ; Fassbender, D ; Trieb, G ; Mannebach, H ; Ohlmeier, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4770-a0cf8f1bde68fcfc7e8da05d8c3b6461addeecdf3bb88596a36f24f10b78e0e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Adult</topic><topic>Cardiac Catheterization</topic><topic>Cineangiography</topic><topic>Coronary Disease - drug therapy</topic><topic>Coronary Disease - physiopathology</topic><topic>Female</topic><topic>Heart - physiopathology</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Metoprolol - therapeutic use</topic><topic>Middle Aged</topic><topic>Pindolol - therapeutic use</topic><topic>Sympathomimetics - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gleichmann, U</creatorcontrib><creatorcontrib>Fassbender, D</creatorcontrib><creatorcontrib>Trieb, G</creatorcontrib><creatorcontrib>Mannebach, H</creatorcontrib><creatorcontrib>Ohlmeier, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gleichmann, U</au><au>Fassbender, D</au><au>Trieb, G</au><au>Mannebach, H</au><au>Ohlmeier, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of beta‐adrenoceptor antagonists with and without intrinsic sympathomimetic activity on local wall motion abnormalities in patients with coronary heart disease</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1982-01-01</date><risdate>1982</risdate><volume>13</volume><issue>S2</issue><spage>301S</spage><epage>304S</epage><pages>301S-304S</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><abstract>1 A single‐blind randomized study of the effects of a beta‐adrenoceptor antagonist with intrinsic sympathomimetic activity (pindolol 0.4 mg i.v., n = 10) and a drug lacking this property (metoprolol 5 mg i.v., n = 11) on local wall motion abnormalities was carried out in 21 patients with coronary heart disease and anterior wall hypokinesia. 2 The drugs produced similar changes in left ventricular end diastolic pressure (LVEDP) and end diastolic volume index (EDVI) but differed in their effects on heart rate and ejection fraction. Pindolol did not exert any marked effect on heart rate or ejection fraction whereas after metoprolol treatment both were significantly decreased. 3 Shortening of the hypokinetic wall segments was improved by both drugs. Shortening of the non‐hypokinetic contralateral segments was unchanged after pindolol administration but was decreased after metoprolol. 4 The differing effects of beta‐adrenoceptor antagonists on regional wall motion appear to be dependent on the presence or absence of intrinsic sympathomimetic activity.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6125180</pmid><doi>10.1111/j.1365-2125.1982.tb01930.x</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 1982-01, Vol.13 (S2), p.301S-304S |
| issn | 0306-5251 1365-2125 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adrenergic beta-Antagonists - therapeutic use Adult Cardiac Catheterization Cineangiography Coronary Disease - drug therapy Coronary Disease - physiopathology Female Heart - physiopathology Heart Rate - drug effects Hemodynamics - drug effects Humans Male Metoprolol - therapeutic use Middle Aged Pindolol - therapeutic use Sympathomimetics - therapeutic use |
| title | The influence of beta‐adrenoceptor antagonists with and without intrinsic sympathomimetic activity on local wall motion abnormalities in patients with coronary heart disease |
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