Rapid reduction of blood pressure with acute oral labetalol
1 The effect of acute oral administration of labetalol on intra‐ arterial pressures in a group of ten hypertensive patients has been evaluated. 2 A single dose of 200 mg labetalol produced a significant reduction in systolic and diastolic pressures within 1 h of administration. 3 Within 24 h of init...
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| Veröffentlicht in: | British journal of clinical pharmacology 1982-05, Vol.13 (5), p.705-710 |
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| container_end_page | 710 |
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| container_title | British journal of clinical pharmacology |
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| creator | Davies, AB Subramanian, Bala V Gould, B Raftery, EB |
| description | 1 The effect of acute oral administration of labetalol on intra‐ arterial pressures in a group of ten hypertensive patients has been evaluated. 2 A single dose of 200 mg labetalol produced a significant reduction in systolic and diastolic pressures within 1 h of administration. 3 Within 24 h of initial administration, 200 mg three times daily produced a significant reduction in ambulant arterial levels of systolic pressure for 21 h and diastolic pressure for 14 h in the day. 4 Acute therapy lowered resting levels but there was no significant reduction in systolic pressure during either isometric or dynamic exercise. 5 Acute therapy was not associated with any significant postural hypotension. |
| doi_str_mv | 10.1111/j.1365-2125.1982.tb01440.x |
| format | Article |
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| ispartof | British journal of clinical pharmacology, 1982-05, Vol.13 (5), p.705-710 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Administration, Oral Adult Aged Blood Pressure - drug effects Ethanolamines - pharmacology Female Heart Rate - drug effects Humans Hypertension - drug therapy Labetalol - pharmacology Labetalol - therapeutic use Male Middle Aged Physical Exertion Posture |
| title | Rapid reduction of blood pressure with acute oral labetalol |
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