Specificity of Mnt ‘master residue’ obtained from in vivo and in vitro selections

Mnt is a repressor from phage P22 that belongs to the ribbon–helix–helix family of DNA binding factors. Four amino acids from the N‐terminus of the protein, Arg2, His6, Asn8 and Arg10, interact with the base pairs of the DNA to provide the sequence specificity. Raumann et al. (Nature Struct. Biol.,...

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Veröffentlicht in:	Nucleic acids research 2002-12, Vol.30 (24), p.5539-5548
Hauptverfasser:	Silbaq, Fauzi S., Ruttenberg, Steven E., Stormo, Gary D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding Sites - genetics Binding, Competitive DNA, Viral - genetics DNA, Viral - metabolism Mutation Oligonucleotides - genetics Oligonucleotides - metabolism Operator Regions, Genetic - genetics Repressor Proteins - genetics Repressor Proteins - metabolism Viral Proteins - genetics Viral Proteins - metabolism Viral Regulatory and Accessory Proteins
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