The characteristics of the cochlear after-potential studied in the guinea-pig by perfusion and stimulation
1. An after-potential which comprises three components can be recorded from scala tympani or scala vestibuli following the termination of a tone burst of more than 20-30 msec duration. The major component is of opposite polarity to the negative summating potential (SP) when recorded from scala tympa...
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| Veröffentlicht in: | The Journal of physiology 1970-09, Vol.210 (2), p.495-505 |
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| creator | Panayiotopoulos, C. P. Stopp, Phyllis E. |
| description | 1. An after-potential which comprises three components can be recorded from scala tympani or scala vestibuli following the
termination of a tone burst of more than 20-30 msec duration. The major component is of opposite polarity to the negative
summating potential (SP) when recorded from scala tympani (ST) and of the same polarity as the SP when recorded from scala
vestibuli.
2. The size of this after-potential is dependent on the duration and strength of the tonal stimulus but not on the stimulus
frequency or its rate of turn-off.
3. A single short tone-pip (10 msec) produces no visible after-potential, but an after-potential is seen following the end
of a train of such pips separated by intervals of similar duration.
4. Replacement of the perilymph in ST by Ringer solution has a negligible effect on the cochlear responses. However, replacing
the sodium ion in Ringer solution by lithium or adding DNP to the perfusate abolishes the after-potential just as in the case
of a neuronal after-potential. The latter manoeuvre affects also the N 1 , CM and SP, while the former does not.
5. It is suggested that there exists an active membrane mechanism at the hair cell/nerve junction, which is responsible for
the after-potential and which can be influenced by perfusion of ST. It is further suggested that this neural mechanism makes
a contribution to the recorded SP over and above the SP component due to non-linear factors. |
| doi_str_mv | 10.1113/jphysiol.1970.sp009222 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1395576</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80790796</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5005-287d4a6e2464a83e353731da4b394490f89d29017e43b0c6ff8714772c81b3a23</originalsourceid><addsrcrecordid>eNqNkc1u1DAUhS1EVaaFRwBlBasM_o3jDRKtoIAqtYthbTnOzcSjTBzshCpvj9NMK9ghWbJ8z7mfj3QQekfwlhDCPh6Gdo7Od1uiJN7GAWNFKX2BNoQXKpdSsZdogzGlOZOCvEIXMR4wJgwrdY7OhcCESrJBh10LmW1NMHaE4OLobMx8k43L2Nu2AxMy0yQtH_wI_ehMl8Vxqh3UmesfffvJ9WDywe2zas4GCM2UkvWZ6etkdcepM2N6v0ZnjekivDndl-jn1y-762_57d3N9-vPt7kVGIuclrLmpgDKC25KBkwwyUhteMUU5wo3paqpwkQCZxW2RdOUknApqS1JxQxll-jTyh2m6gi1TaGD6fQQ3NGEWXvj9L9K71q99781YUoIWSTA-xMg-F8TxFEfXbTQdaYHP0VdYqnSWYzFarTBxxigef6EYL20pJ9a0ktL-qmltPj274jPa6dakn616g-ug_k_qXr3434ZUIIpVyJBPqyQ1u3bBxdAr2vRWwfjrJNPU704_wC3orXE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80790796</pqid></control><display><type>article</type><title>The characteristics of the cochlear after-potential studied in the guinea-pig by perfusion and stimulation</title><source>MEDLINE</source><source>Wiley Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Panayiotopoulos, C. P. ; Stopp, Phyllis E.</creator><creatorcontrib>Panayiotopoulos, C. P. ; Stopp, Phyllis E.</creatorcontrib><description>1. An after-potential which comprises three components can be recorded from scala tympani or scala vestibuli following the
termination of a tone burst of more than 20-30 msec duration. The major component is of opposite polarity to the negative
summating potential (SP) when recorded from scala tympani (ST) and of the same polarity as the SP when recorded from scala
vestibuli.
2. The size of this after-potential is dependent on the duration and strength of the tonal stimulus but not on the stimulus
frequency or its rate of turn-off.
3. A single short tone-pip (10 msec) produces no visible after-potential, but an after-potential is seen following the end
of a train of such pips separated by intervals of similar duration.
4. Replacement of the perilymph in ST by Ringer solution has a negligible effect on the cochlear responses. However, replacing
the sodium ion in Ringer solution by lithium or adding DNP to the perfusate abolishes the after-potential just as in the case
of a neuronal after-potential. The latter manoeuvre affects also the N 1 , CM and SP, while the former does not.
5. It is suggested that there exists an active membrane mechanism at the hair cell/nerve junction, which is responsible for
the after-potential and which can be influenced by perfusion of ST. It is further suggested that this neural mechanism makes
a contribution to the recorded SP over and above the SP component due to non-linear factors.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1970.sp009222</identifier><identifier>PMID: 5501271</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Animals ; Biological Transport, Active - drug effects ; Cell Membrane Permeability - drug effects ; Cochlea - physiology ; Dinitrophenols - pharmacology</subject><ispartof>The Journal of physiology, 1970-09, Vol.210 (2), p.495-505</ispartof><rights>1970 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5005-287d4a6e2464a83e353731da4b394490f89d29017e43b0c6ff8714772c81b3a23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395576/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395576/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5501271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Panayiotopoulos, C. P.</creatorcontrib><creatorcontrib>Stopp, Phyllis E.</creatorcontrib><title>The characteristics of the cochlear after-potential studied in the guinea-pig by perfusion and stimulation</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. An after-potential which comprises three components can be recorded from scala tympani or scala vestibuli following the
termination of a tone burst of more than 20-30 msec duration. The major component is of opposite polarity to the negative
summating potential (SP) when recorded from scala tympani (ST) and of the same polarity as the SP when recorded from scala
vestibuli.
2. The size of this after-potential is dependent on the duration and strength of the tonal stimulus but not on the stimulus
frequency or its rate of turn-off.
3. A single short tone-pip (10 msec) produces no visible after-potential, but an after-potential is seen following the end
of a train of such pips separated by intervals of similar duration.
4. Replacement of the perilymph in ST by Ringer solution has a negligible effect on the cochlear responses. However, replacing
the sodium ion in Ringer solution by lithium or adding DNP to the perfusate abolishes the after-potential just as in the case
of a neuronal after-potential. The latter manoeuvre affects also the N 1 , CM and SP, while the former does not.
5. It is suggested that there exists an active membrane mechanism at the hair cell/nerve junction, which is responsible for
the after-potential and which can be influenced by perfusion of ST. It is further suggested that this neural mechanism makes
a contribution to the recorded SP over and above the SP component due to non-linear factors.</description><subject>Animals</subject><subject>Biological Transport, Active - drug effects</subject><subject>Cell Membrane Permeability - drug effects</subject><subject>Cochlea - physiology</subject><subject>Dinitrophenols - pharmacology</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhS1EVaaFRwBlBasM_o3jDRKtoIAqtYthbTnOzcSjTBzshCpvj9NMK9ghWbJ8z7mfj3QQekfwlhDCPh6Gdo7Od1uiJN7GAWNFKX2BNoQXKpdSsZdogzGlOZOCvEIXMR4wJgwrdY7OhcCESrJBh10LmW1NMHaE4OLobMx8k43L2Nu2AxMy0yQtH_wI_ehMl8Vxqh3UmesfffvJ9WDywe2zas4GCM2UkvWZ6etkdcepM2N6v0ZnjekivDndl-jn1y-762_57d3N9-vPt7kVGIuclrLmpgDKC25KBkwwyUhteMUU5wo3paqpwkQCZxW2RdOUknApqS1JxQxll-jTyh2m6gi1TaGD6fQQ3NGEWXvj9L9K71q99781YUoIWSTA-xMg-F8TxFEfXbTQdaYHP0VdYqnSWYzFarTBxxigef6EYL20pJ9a0ktL-qmltPj274jPa6dakn616g-ug_k_qXr3434ZUIIpVyJBPqyQ1u3bBxdAr2vRWwfjrJNPU704_wC3orXE</recordid><startdate>19700901</startdate><enddate>19700901</enddate><creator>Panayiotopoulos, C. P.</creator><creator>Stopp, Phyllis E.</creator><general>The Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19700901</creationdate><title>The characteristics of the cochlear after-potential studied in the guinea-pig by perfusion and stimulation</title><author>Panayiotopoulos, C. P. ; Stopp, Phyllis E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5005-287d4a6e2464a83e353731da4b394490f89d29017e43b0c6ff8714772c81b3a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Animals</topic><topic>Biological Transport, Active - drug effects</topic><topic>Cell Membrane Permeability - drug effects</topic><topic>Cochlea - physiology</topic><topic>Dinitrophenols - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panayiotopoulos, C. P.</creatorcontrib><creatorcontrib>Stopp, Phyllis E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Panayiotopoulos, C. P.</au><au>Stopp, Phyllis E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The characteristics of the cochlear after-potential studied in the guinea-pig by perfusion and stimulation</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1970-09-01</date><risdate>1970</risdate><volume>210</volume><issue>2</issue><spage>495</spage><epage>505</epage><pages>495-505</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. An after-potential which comprises three components can be recorded from scala tympani or scala vestibuli following the
termination of a tone burst of more than 20-30 msec duration. The major component is of opposite polarity to the negative
summating potential (SP) when recorded from scala tympani (ST) and of the same polarity as the SP when recorded from scala
vestibuli.
2. The size of this after-potential is dependent on the duration and strength of the tonal stimulus but not on the stimulus
frequency or its rate of turn-off.
3. A single short tone-pip (10 msec) produces no visible after-potential, but an after-potential is seen following the end
of a train of such pips separated by intervals of similar duration.
4. Replacement of the perilymph in ST by Ringer solution has a negligible effect on the cochlear responses. However, replacing
the sodium ion in Ringer solution by lithium or adding DNP to the perfusate abolishes the after-potential just as in the case
of a neuronal after-potential. The latter manoeuvre affects also the N 1 , CM and SP, while the former does not.
5. It is suggested that there exists an active membrane mechanism at the hair cell/nerve junction, which is responsible for
the after-potential and which can be influenced by perfusion of ST. It is further suggested that this neural mechanism makes
a contribution to the recorded SP over and above the SP component due to non-linear factors.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>5501271</pmid><doi>10.1113/jphysiol.1970.sp009222</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3751 |
| ispartof | The Journal of physiology, 1970-09, Vol.210 (2), p.495-505 |
| issn | 0022-3751 1469-7793 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1395576 |
| source | MEDLINE; Wiley Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Biological Transport, Active - drug effects Cell Membrane Permeability - drug effects Cochlea - physiology Dinitrophenols - pharmacology |
| title | The characteristics of the cochlear after-potential studied in the guinea-pig by perfusion and stimulation |
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