A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

P2X 3 and P2X 2/3 receptors are highly localized on peripheral and central processes of sensory afferent nerves, and activation of these channels contributes to the pronociceptive effects of ATP. A-317491 is a novel non-nucleotide antagonist of P2X 3 and P2X 2/3 receptor activation. A-317491 potentl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-12, Vol.99 (26), p.17179-17184
Hauptverfasser:	Jarvis, Michael F, Burgard, Edward C, McGaraughty, Steve, Honore, Prisca, Lynch, Kevin, Brennan, Timothy J, Subieta, Alberto, Van Biesen, Tim, Cartmell, Jayne, Bianchi, Bruce, Niforatos, Wende, Kage, Karen, Yu, Haixia, Mikusa, Joe, Wismer, Carol T, Zhu, Chang Z, Chu, Katharine, Lee, Chih-Hung, Stewart, Andrew O, Polakowski, James, Cox, Bryan F, Kowaluk, Elizabeth, Williams, Michael, Sullivan, James, Faltynek, Connie
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics, Non-Narcotic - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological Sciences Brain - drug effects Brain - physiology Dose-Response Relationship, Drug Hemodynamics - drug effects Male Motor Activity - drug effects Pain management Pharmacology Phenols - pharmacology Polycyclic Compounds - pharmacology Purinergic P2 Receptor Antagonists Rats Rats, Sprague-Dawley Receptors, Purinergic P2X2 Receptors, Purinergic P2X3 Rodents
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!