Beta‐adrenoceptor responses to high doses of inhaled salbutamol in patients with bronchial asthma

1. Fourteen asthmatics (mean +/‐ s.e. mean baseline FEV1 62 +/‐ 6% of predicted) were given cumulative doubling doses of salbutamol by metered‐dose inhaler as follows: 100 micrograms, 200 micrograms, 500 micrograms, 1000 micrograms, 2000 micrograms, 4000 micrograms. 2. Airways, tremor, haemodynamic...

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Veröffentlicht in:	British journal of clinical pharmacology 1988-11, Vol.26 (5), p.527-533
Hauptverfasser:	Lipworth, BJ, Clark, RA, Dhillon, DP, Brown, RA, McDevitt, DG
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adult Aged Albuterol - administration & dosage Albuterol - adverse effects Albuterol - therapeutic use Asthma - drug therapy Asthma - physiopathology Biological and medical sciences Blood Pressure - drug effects Cyclic AMP - blood Dose-Response Relationship, Drug Female Heart Rate - drug effects Humans Medical sciences Middle Aged Pharmacology. Drug treatments Pulmonary Ventilation - drug effects Receptors, Adrenergic, beta - drug effects Respiratory system Time Factors Tremor - chemically induced Vital Capacity - drug effects
Online-Zugang:	Volltext
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