Allopurinol dosage selection: relationships between dose and plasma oxipurinol and urate concentrations and urinary urate excretion
1. Allopurinol usage in 50 patients of a city teaching hospital was surveyed. 2. The plasma concentrations of oxipurinol and uric acid and the urinary production of uric acid were examined. 3. The daily doses of allopurinol ranged from 50 to 1200 mg but 83% of patients were taking 300 mg daily. 4. A...
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| Veröffentlicht in: | British journal of clinical pharmacology 1988-10, Vol.26 (4), p.423-428 |
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| container_title | British journal of clinical pharmacology |
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| creator | Day, RO Miners, JO Birkett, DJ Whitehead, A Naidoo, D Hayes, J Savdie, E |
| description | 1. Allopurinol usage in 50 patients of a city teaching hospital was surveyed. 2. The plasma concentrations of oxipurinol and uric acid and the urinary production of uric acid were examined. 3. The daily doses of allopurinol ranged from 50 to 1200 mg but 83% of patients were taking 300 mg daily. 4. A wide range of plasma oxipurinol concentrations was observed from 2.8 to 55.8 mg l‐1 with a mean +/‐ s.d. of 15.2 +/‐ 11.7 mg l‐1. 5. The population studied included a high proportion of patients with renal impairment and creatinine clearance was a significant determinant of oxipurinol concentrations (P less than 0.005). 6. There was no significant correlation between plasma urate and plasma oxipurinol concentrations and only a few plasma urates were above the upper limit of the reference range of the laboratory. 7. It was apparent that many patients were taking unnecessarily high daily doses of allopurinol and that renal status was not always considered when deciding dosage regimens of allopurinol. |
| doi_str_mv | 10.1111/j.1365-2125.1988.tb03401.x |
| format | Article |
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Allopurinol usage in 50 patients of a city teaching hospital was surveyed. 2. The plasma concentrations of oxipurinol and uric acid and the urinary production of uric acid were examined. 3. The daily doses of allopurinol ranged from 50 to 1200 mg but 83% of patients were taking 300 mg daily. 4. A wide range of plasma oxipurinol concentrations was observed from 2.8 to 55.8 mg l‐1 with a mean +/‐ s.d. of 15.2 +/‐ 11.7 mg l‐1. 5. The population studied included a high proportion of patients with renal impairment and creatinine clearance was a significant determinant of oxipurinol concentrations (P less than 0.005). 6. There was no significant correlation between plasma urate and plasma oxipurinol concentrations and only a few plasma urates were above the upper limit of the reference range of the laboratory. 7. It was apparent that many patients were taking unnecessarily high daily doses of allopurinol and that renal status was not always considered when deciding dosage regimens of allopurinol.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.1988.tb03401.x</identifier><identifier>PMID: 3190992</identifier><identifier>CODEN: BCPHBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Allopurinol - administration & dosage ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Oxypurinol - blood ; Pharmacology. Drug treatments ; Pyrimidines - blood ; Uric Acid - metabolism ; Urinary system ; Xanthine ; Xanthines - blood</subject><ispartof>British journal of clinical pharmacology, 1988-10, Vol.26 (4), p.423-428</ispartof><rights>1988 The British Pharmacological Society</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5721-82774e17fdfeda8a7fe0f0bc1ae4fc021d5de0bac202ecf776221685932a43903</citedby><cites>FETCH-LOGICAL-c5721-82774e17fdfeda8a7fe0f0bc1ae4fc021d5de0bac202ecf776221685932a43903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7307354$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3190992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Day, RO</creatorcontrib><creatorcontrib>Miners, JO</creatorcontrib><creatorcontrib>Birkett, DJ</creatorcontrib><creatorcontrib>Whitehead, A</creatorcontrib><creatorcontrib>Naidoo, D</creatorcontrib><creatorcontrib>Hayes, J</creatorcontrib><creatorcontrib>Savdie, E</creatorcontrib><title>Allopurinol dosage selection: relationships between dose and plasma oxipurinol and urate concentrations and urinary urate excretion</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>1. Allopurinol usage in 50 patients of a city teaching hospital was surveyed. 2. The plasma concentrations of oxipurinol and uric acid and the urinary production of uric acid were examined. 3. The daily doses of allopurinol ranged from 50 to 1200 mg but 83% of patients were taking 300 mg daily. 4. A wide range of plasma oxipurinol concentrations was observed from 2.8 to 55.8 mg l‐1 with a mean +/‐ s.d. of 15.2 +/‐ 11.7 mg l‐1. 5. The population studied included a high proportion of patients with renal impairment and creatinine clearance was a significant determinant of oxipurinol concentrations (P less than 0.005). 6. There was no significant correlation between plasma urate and plasma oxipurinol concentrations and only a few plasma urates were above the upper limit of the reference range of the laboratory. 7. It was apparent that many patients were taking unnecessarily high daily doses of allopurinol and that renal status was not always considered when deciding dosage regimens of allopurinol.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Allopurinol - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oxypurinol - blood</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrimidines - blood</subject><subject>Uric Acid - metabolism</subject><subject>Urinary system</subject><subject>Xanthine</subject><subject>Xanthines - blood</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc1u1DAUhS1EVYbCIyBFCLFL8E8cJ12AyghKpUqwgLXlODetRx472AmdrnnxxkoYlWW98ZXPd4-PdBB6S3BB5vNhVxBW8ZwSygvS1HUxtpiVmBSHZ2hzlJ6jDWa4yjnl5AV6GeMOY8JIxU_RKSMNbhq6QX8vrPXDFIzzNut8VDeQRbCgR-PdeRbAqjTFWzPErIXxDsAlDjLlumywKu5V5g_mn0V6nYIaIdPeaXBjWPZXwTgV7lcADjpAEl-hk17ZCK_X-wz9-vrl5_Zbfv398mp7cZ1rLijJaypECUT0XQ-dqpXoAfe41URB2WtMScc7wK3SFFPQvRAVpaSqecOoKlmD2Rn6uPgOU7uHbkln5RDMfk4lvTLyf8WZW3nj_0jC6opX5WzwfjUI_vcEcZR7EzVYqxz4KUpR85JiRmbwfAF18DEG6I-fECxThXInU08y9SRThXKtUB7m5TePYx5X185m_d2qq6iV7YNy2sQjJhgWjKewnxbszli4f0IA-Xn7I03sAWKqvjk</recordid><startdate>198810</startdate><enddate>198810</enddate><creator>Day, RO</creator><creator>Miners, JO</creator><creator>Birkett, DJ</creator><creator>Whitehead, A</creator><creator>Naidoo, D</creator><creator>Hayes, J</creator><creator>Savdie, E</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>198810</creationdate><title>Allopurinol dosage selection: relationships between dose and plasma oxipurinol and urate concentrations and urinary urate excretion</title><author>Day, RO ; Miners, JO ; Birkett, DJ ; Whitehead, A ; Naidoo, D ; Hayes, J ; Savdie, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5721-82774e17fdfeda8a7fe0f0bc1ae4fc021d5de0bac202ecf776221685932a43903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Allopurinol - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oxypurinol - blood</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrimidines - blood</topic><topic>Uric Acid - metabolism</topic><topic>Urinary system</topic><topic>Xanthine</topic><topic>Xanthines - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Day, RO</creatorcontrib><creatorcontrib>Miners, JO</creatorcontrib><creatorcontrib>Birkett, DJ</creatorcontrib><creatorcontrib>Whitehead, A</creatorcontrib><creatorcontrib>Naidoo, D</creatorcontrib><creatorcontrib>Hayes, J</creatorcontrib><creatorcontrib>Savdie, E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Day, RO</au><au>Miners, JO</au><au>Birkett, DJ</au><au>Whitehead, A</au><au>Naidoo, D</au><au>Hayes, J</au><au>Savdie, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allopurinol dosage selection: relationships between dose and plasma oxipurinol and urate concentrations and urinary urate excretion</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1988-10</date><risdate>1988</risdate><volume>26</volume><issue>4</issue><spage>423</spage><epage>428</epage><pages>423-428</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><coden>BCPHBM</coden><abstract>1. Allopurinol usage in 50 patients of a city teaching hospital was surveyed. 2. The plasma concentrations of oxipurinol and uric acid and the urinary production of uric acid were examined. 3. The daily doses of allopurinol ranged from 50 to 1200 mg but 83% of patients were taking 300 mg daily. 4. A wide range of plasma oxipurinol concentrations was observed from 2.8 to 55.8 mg l‐1 with a mean +/‐ s.d. of 15.2 +/‐ 11.7 mg l‐1. 5. The population studied included a high proportion of patients with renal impairment and creatinine clearance was a significant determinant of oxipurinol concentrations (P less than 0.005). 6. There was no significant correlation between plasma urate and plasma oxipurinol concentrations and only a few plasma urates were above the upper limit of the reference range of the laboratory. 7. It was apparent that many patients were taking unnecessarily high daily doses of allopurinol and that renal status was not always considered when deciding dosage regimens of allopurinol.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3190992</pmid><doi>10.1111/j.1365-2125.1988.tb03401.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Allopurinol - administration & dosage Biological and medical sciences Dose-Response Relationship, Drug Female Humans Male Medical sciences Middle Aged Oxypurinol - blood Pharmacology. Drug treatments Pyrimidines - blood Uric Acid - metabolism Urinary system Xanthine Xanthines - blood |
| title | Allopurinol dosage selection: relationships between dose and plasma oxipurinol and urate concentrations and urinary urate excretion |
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