Going nuclear in metabolic and cardiovascular disease
Estrogen receptors, PPARs, and liver X receptors are members of the nuclear receptor superfamily of ligand-dependent transcription factors that regulate diverse aspects of development and homeostasis. Recent studies of the biologic roles of these receptors and their mechanisms of action have signifi...
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| Veröffentlicht in: | The Journal of clinical investigation 2006-03, Vol.116 (3), p.556-560 |
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| container_title | The Journal of clinical investigation |
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| creator | Glass, Christopher K |
| description | Estrogen receptors, PPARs, and liver X receptors are members of the nuclear receptor superfamily of ligand-dependent transcription factors that regulate diverse aspects of development and homeostasis. Recent studies of the biologic roles of these receptors and their mechanisms of action have significantly advanced our understanding of transcriptional programs that control lipid and carbohydrate metabolism, immunity and inflammation, and wound repair. These findings provide insights into the therapeutic actions of existing drugs that target nuclear receptors and raise new possibilities for development of safer, more effective drugs for the prevention and treatment of metabolic and cardiovascular diseases. In this introduction to this Review series, underlying mechanisms that enable nuclear receptors to positively and negatively regulate gene expression are presented as background to the focused reviews on estrogen receptors, PPARs, liver X receptors, and the PPARgamma coactivator-1 (PGC-1) family of coactivators. |
| doi_str_mv | 10.1172/jci27913 |
| format | Article |
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metabolism</subject><subject>Receptors, Cytoplasmic and Nuclear - physiology</subject><subject>Review Series</subject><subject>Signal transduction</subject><subject>Steroids</subject><subject>Thyroid gland</subject><subject>Transcription factors</subject><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtrFEEUhYugmHEU_AXSuAhuOt5b794IYciTQDa6Lu5UVccaerpi1XQg_z5tMhh14-ouzsfhnHsY-4BwjGj4l41P3HQoDtgClbKt5cK-YgsAjm1nhD1kb2vdAKCUSr5hh6gVorJmwdR5TuNtM05-iFSaNDbbuKN1HpJvaAyNpxJSvqfqp2HWQ6qRanzHXvc01Ph-f5fs-9npt9VFe31zfrk6uW697OSu5TqCBMWBeNQdwVqgl701EjyoKNdciF6TD7KnQCht4GSDx85K6rkIVizZ12ffu2m9jcHHcVdocHclbak8uEzJ_a2M6Ye7zfcOhdWIejY42huU_HOKdee2qfo4DDTGPFWnjQFttfovyEGaTgLO4Kd_wE2eyjh_YWZACQNzqyX7_Az5kmstsf8dGcH9WsxdrS6fFpvRj39WfAH3E4lHfx-QLw</recordid><startdate>200603</startdate><enddate>200603</enddate><creator>Glass, Christopher K</creator><general>American Society for Clinical Investigation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200603</creationdate><title>Going nuclear in metabolic and cardiovascular disease</title><author>Glass, Christopher K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-26e040520a2e69a0b31c4f8740c05e4b233f6acd4fada148d2a8dc1984af23d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biomedical research</topic><topic>Cardiovascular Diseases - 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Biomedical research Cardiovascular Diseases - metabolism Cardiovascular Diseases - prevention & control Cholesterol Conflicts of interest Estrogens Gene expression Homeostasis Hormones Humans Ligands Lipids Liver Metabolic Diseases - metabolism Metabolic Diseases - prevention & control Metabolism Metabolites Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Cytoplasmic and Nuclear - physiology Review Series Signal transduction Steroids Thyroid gland Transcription factors |
| title | Going nuclear in metabolic and cardiovascular disease |
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