The role of PACT in the RNA silencing pathway

Small RNA‐mediated gene silencing (RNA silencing) has emerged as a major regulatory pathway in eukaryotes. Identification of the key factors involved in this pathway has been a subject of rigorous investigation in recent years. In humans, small RNAs are generated by Dicer and assembled into the effe...

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Veröffentlicht in:	The EMBO journal 2006-02, Vol.25 (3), p.522-532
Hauptverfasser:	Lee, Yoontae, Hur, Inha, Park, Seong-Yeon, Kim, Young-Kook, Suh, Mi Ra, Kim, V Narry
Format:	Artikel
Sprache:	eng
Schlagworte:	Argonaute Proteins Cell Line Dicer EMBO36 Eukaryotic Initiation Factor-2 Human immunodeficiency virus 1 Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism microRNA MicroRNAs - genetics MicroRNAs - metabolism Nuclear Receptor Coactivators PACT Peptide Initiation Factors - genetics Peptide Initiation Factors - metabolism Protein Binding Protein Structure, Tertiary - genetics Protein Structure, Tertiary - physiology Proteins Ribonuclease III - genetics Ribonuclease III - metabolism RNA Interference RNA, Double-Stranded - genetics RNA, Double-Stranded - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism RNA-Induced Silencing Complex - genetics RNA-Induced Silencing Complex - metabolism RNAi Signal Transduction siRNA
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