Azathioprine pharmacokinetics after intravenous, oral, delayed release oral and rectal foam administration

BACKGROUND: 6-Mercaptopurine and its prodrug azathioprine are effective medications for refractory inflammatory bowel disease. However, use of these drugs has been limited by concerns about their toxicity. Colonic delivery of azathioprine may reduce its systemic bioavailability and limit toxicity. A...

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Veröffentlicht in:	Gut 1996-07, Vol.39 (1), p.63-68
Hauptverfasser:	Van Os, E C, Zins, B J, Sandborn, W J, Mays, D C, Tremaine, W J, Mahoney, D W, Zinsmeister, A R, Lipsky, J J
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Administration, Rectal Adult Azathioprine - administration & dosage Azathioprine - pharmacokinetics Chromatography, High Pressure Liquid Delayed-Action Preparations Female Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacokinetics Male Mercaptopurine - blood Middle Aged
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