Unconjugated secondary bile acids in the serum of patients with colorectal adenomas
A positive association between deoxcholic acid (DCA) in the serum and colorectal adenomas, the precursors of colorectal cancer has recently been found, which supported the hypothesis of a pathogenic role of DCA in colonic carcinogenesis. This approach was based on the hypothesis that DCA formed in t...
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| Veröffentlicht in: | Gut 1995-02, Vol.36 (2), p.268-273 |
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| creator | Bayerdörffer, E Mannes, G A Ochsenkühn, T Dirschedl, P Wiebecke, B Paumgartner, G |
| description | A positive association between deoxcholic acid (DCA) in the serum and colorectal adenomas, the precursors of colorectal cancer has recently been found, which supported the hypothesis of a pathogenic role of DCA in colonic carcinogenesis. This approach was based on the hypothesis that DCA formed in the colon is absorbed into the portal venous blood and exhibits a constant spillover to the systemic circulation. To further substantiate this hypothesis this study investigated whether in the serum of adenoma patients DCA was higher in the unconjugated fraction, which originates directly from the colon. DCA was found to be 2.8-fold higher in the unconjugated fraction of patients with colorectal adenomas than in controls (0.89 v 0.32 mumol/l, p < 0.0025), 1.9-fold in the total DCA fraction (1.89 v 0.95 mumol/l, p < 0.0001), and 1.4-fold in the conjugated fraction (0.67 v 0.47 mumol/l, p < 0.05). It was further found that the bacterial isomerisation product 3 beta-DCA was twofold higher in the unconjugated fraction of adenoma patients than in controls (0.08 v 0.04 mumol/l, p = 0.27), 1.8-fold in the total iso-DCA fraction (0.11 v 0.06 mumol/l, p < 0.05), and 1.5-fold in the conjugated iso-DCA fraction (0.03 v 0.02 mumol/l, p = 0.68). The data suggest that the positive association between the serum DCA concentration and colorectal adenoma as described previously results from the DCA fraction that is absorbed from the colon. This further supports a pathogenic role of DCA in the carcinogenesis of colorectal cancer. |
| doi_str_mv | 10.1136/gut.36.2.268 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1382415</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3970002121</sourcerecordid><originalsourceid>FETCH-LOGICAL-b506t-16fe23ce4e3d66f875bea82ed7629ef64fd65ef54a4fe66651db2d63370df0ad3</originalsourceid><addsrcrecordid>eNp9kc2LFDEQxYMo6-zqzasQUPBij_noTtIXQQbXFZbxoCveQrpTmcnY3RmTtOv-9xuZYdDLnori_Xj1kofQC0qWlHLxbjPnJRdLtmRCPUILWgtVcabUY7QghMqqkXX7FJ2ntCOEKNXSM3QmleKMqQX6ejP1YdrNG5PB4gRlsSbe4c4PgE3vbcJ-wnkLRYvziIPDe5M9TDnhW5-3uA9DiNBnM2BjYQqjSc_QE2eGBM-P8wLdXH78trqqrr98-rz6cF11DRG5osIB4z3UwK0QTsmmA6MYWClYC07UzooGXFOb2oEQoqG2Y1ZwLol1xFh-gd4ffPdzN4LtS6hoBr2PfixP0MF4_b8y-a3ehN-acsVq2hSDV0eDGH7NkLLehTlOJbOmUhIiaFvLQr09UH0MKUVwpwuU6L8N6NKALoPp0kDBX_6b6gQfv7zor4-6Sb0ZXDRT79MJ4yWYqlnBqgPmU4Y_J9nEn1pILhu9_r7SP_glF-u10m3h3xz4btw9HPAe6KWsRg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1770061947</pqid></control><display><type>article</type><title>Unconjugated secondary bile acids in the serum of patients with colorectal adenomas</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Bayerdörffer, E ; Mannes, G A ; Ochsenkühn, T ; Dirschedl, P ; Wiebecke, B ; Paumgartner, G</creator><creatorcontrib>Bayerdörffer, E ; Mannes, G A ; Ochsenkühn, T ; Dirschedl, P ; Wiebecke, B ; Paumgartner, G</creatorcontrib><description>A positive association between deoxcholic acid (DCA) in the serum and colorectal adenomas, the precursors of colorectal cancer has recently been found, which supported the hypothesis of a pathogenic role of DCA in colonic carcinogenesis. This approach was based on the hypothesis that DCA formed in the colon is absorbed into the portal venous blood and exhibits a constant spillover to the systemic circulation. To further substantiate this hypothesis this study investigated whether in the serum of adenoma patients DCA was higher in the unconjugated fraction, which originates directly from the colon. DCA was found to be 2.8-fold higher in the unconjugated fraction of patients with colorectal adenomas than in controls (0.89 v 0.32 mumol/l, p < 0.0025), 1.9-fold in the total DCA fraction (1.89 v 0.95 mumol/l, p < 0.0001), and 1.4-fold in the conjugated fraction (0.67 v 0.47 mumol/l, p < 0.05). It was further found that the bacterial isomerisation product 3 beta-DCA was twofold higher in the unconjugated fraction of adenoma patients than in controls (0.08 v 0.04 mumol/l, p = 0.27), 1.8-fold in the total iso-DCA fraction (0.11 v 0.06 mumol/l, p < 0.05), and 1.5-fold in the conjugated iso-DCA fraction (0.03 v 0.02 mumol/l, p = 0.68). The data suggest that the positive association between the serum DCA concentration and colorectal adenoma as described previously results from the DCA fraction that is absorbed from the colon. This further supports a pathogenic role of DCA in the carcinogenesis of colorectal cancer.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>EISSN: 1458-3288</identifier><identifier>DOI: 10.1136/gut.36.2.268</identifier><identifier>PMID: 7883228</identifier><identifier>CODEN: GUTTAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Adenoma - blood ; Bile Acids and Salts - blood ; Biological and medical sciences ; Cocarcinogenesis ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - etiology ; Deoxycholic Acid - blood ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Middle Aged ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Gut, 1995-02, Vol.36 (2), p.268-273</ispartof><rights>1995 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Feb 1995</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b506t-16fe23ce4e3d66f875bea82ed7629ef64fd65ef54a4fe66651db2d63370df0ad3</citedby><cites>FETCH-LOGICAL-b506t-16fe23ce4e3d66f875bea82ed7629ef64fd65ef54a4fe66651db2d63370df0ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1382415/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1382415/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3415842$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7883228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bayerdörffer, E</creatorcontrib><creatorcontrib>Mannes, G A</creatorcontrib><creatorcontrib>Ochsenkühn, T</creatorcontrib><creatorcontrib>Dirschedl, P</creatorcontrib><creatorcontrib>Wiebecke, B</creatorcontrib><creatorcontrib>Paumgartner, G</creatorcontrib><title>Unconjugated secondary bile acids in the serum of patients with colorectal adenomas</title><title>Gut</title><addtitle>Gut</addtitle><description>A positive association between deoxcholic acid (DCA) in the serum and colorectal adenomas, the precursors of colorectal cancer has recently been found, which supported the hypothesis of a pathogenic role of DCA in colonic carcinogenesis. This approach was based on the hypothesis that DCA formed in the colon is absorbed into the portal venous blood and exhibits a constant spillover to the systemic circulation. To further substantiate this hypothesis this study investigated whether in the serum of adenoma patients DCA was higher in the unconjugated fraction, which originates directly from the colon. DCA was found to be 2.8-fold higher in the unconjugated fraction of patients with colorectal adenomas than in controls (0.89 v 0.32 mumol/l, p < 0.0025), 1.9-fold in the total DCA fraction (1.89 v 0.95 mumol/l, p < 0.0001), and 1.4-fold in the conjugated fraction (0.67 v 0.47 mumol/l, p < 0.05). It was further found that the bacterial isomerisation product 3 beta-DCA was twofold higher in the unconjugated fraction of adenoma patients than in controls (0.08 v 0.04 mumol/l, p = 0.27), 1.8-fold in the total iso-DCA fraction (0.11 v 0.06 mumol/l, p < 0.05), and 1.5-fold in the conjugated iso-DCA fraction (0.03 v 0.02 mumol/l, p = 0.68). The data suggest that the positive association between the serum DCA concentration and colorectal adenoma as described previously results from the DCA fraction that is absorbed from the colon. This further supports a pathogenic role of DCA in the carcinogenesis of colorectal cancer.</description><subject>Adenoma - blood</subject><subject>Bile Acids and Salts - blood</subject><subject>Biological and medical sciences</subject><subject>Cocarcinogenesis</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - etiology</subject><subject>Deoxycholic Acid - blood</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0017-5749</issn><issn>1468-3288</issn><issn>1458-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc2LFDEQxYMo6-zqzasQUPBij_noTtIXQQbXFZbxoCveQrpTmcnY3RmTtOv-9xuZYdDLnori_Xj1kofQC0qWlHLxbjPnJRdLtmRCPUILWgtVcabUY7QghMqqkXX7FJ2ntCOEKNXSM3QmleKMqQX6ejP1YdrNG5PB4gRlsSbe4c4PgE3vbcJ-wnkLRYvziIPDe5M9TDnhW5-3uA9DiNBnM2BjYQqjSc_QE2eGBM-P8wLdXH78trqqrr98-rz6cF11DRG5osIB4z3UwK0QTsmmA6MYWClYC07UzooGXFOb2oEQoqG2Y1ZwLol1xFh-gd4ffPdzN4LtS6hoBr2PfixP0MF4_b8y-a3ehN-acsVq2hSDV0eDGH7NkLLehTlOJbOmUhIiaFvLQr09UH0MKUVwpwuU6L8N6NKALoPp0kDBX_6b6gQfv7zor4-6Sb0ZXDRT79MJ4yWYqlnBqgPmU4Y_J9nEn1pILhu9_r7SP_glF-u10m3h3xz4btw9HPAe6KWsRg</recordid><startdate>19950201</startdate><enddate>19950201</enddate><creator>Bayerdörffer, E</creator><creator>Mannes, G A</creator><creator>Ochsenkühn, T</creator><creator>Dirschedl, P</creator><creator>Wiebecke, B</creator><creator>Paumgartner, G</creator><general>BMJ Publishing Group Ltd and British Society of Gastroenterology</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>19950201</creationdate><title>Unconjugated secondary bile acids in the serum of patients with colorectal adenomas</title><author>Bayerdörffer, E ; Mannes, G A ; Ochsenkühn, T ; Dirschedl, P ; Wiebecke, B ; Paumgartner, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b506t-16fe23ce4e3d66f875bea82ed7629ef64fd65ef54a4fe66651db2d63370df0ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adenoma - blood</topic><topic>Bile Acids and Salts - blood</topic><topic>Biological and medical sciences</topic><topic>Cocarcinogenesis</topic><topic>Colorectal Neoplasms - blood</topic><topic>Colorectal Neoplasms - etiology</topic><topic>Deoxycholic Acid - blood</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bayerdörffer, E</creatorcontrib><creatorcontrib>Mannes, G A</creatorcontrib><creatorcontrib>Ochsenkühn, T</creatorcontrib><creatorcontrib>Dirschedl, P</creatorcontrib><creatorcontrib>Wiebecke, B</creatorcontrib><creatorcontrib>Paumgartner, G</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bayerdörffer, E</au><au>Mannes, G A</au><au>Ochsenkühn, T</au><au>Dirschedl, P</au><au>Wiebecke, B</au><au>Paumgartner, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unconjugated secondary bile acids in the serum of patients with colorectal adenomas</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>1995-02-01</date><risdate>1995</risdate><volume>36</volume><issue>2</issue><spage>268</spage><epage>273</epage><pages>268-273</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><eissn>1458-3288</eissn><coden>GUTTAK</coden><abstract>A positive association between deoxcholic acid (DCA) in the serum and colorectal adenomas, the precursors of colorectal cancer has recently been found, which supported the hypothesis of a pathogenic role of DCA in colonic carcinogenesis. This approach was based on the hypothesis that DCA formed in the colon is absorbed into the portal venous blood and exhibits a constant spillover to the systemic circulation. To further substantiate this hypothesis this study investigated whether in the serum of adenoma patients DCA was higher in the unconjugated fraction, which originates directly from the colon. DCA was found to be 2.8-fold higher in the unconjugated fraction of patients with colorectal adenomas than in controls (0.89 v 0.32 mumol/l, p < 0.0025), 1.9-fold in the total DCA fraction (1.89 v 0.95 mumol/l, p < 0.0001), and 1.4-fold in the conjugated fraction (0.67 v 0.47 mumol/l, p < 0.05). It was further found that the bacterial isomerisation product 3 beta-DCA was twofold higher in the unconjugated fraction of adenoma patients than in controls (0.08 v 0.04 mumol/l, p = 0.27), 1.8-fold in the total iso-DCA fraction (0.11 v 0.06 mumol/l, p < 0.05), and 1.5-fold in the conjugated iso-DCA fraction (0.03 v 0.02 mumol/l, p = 0.68). The data suggest that the positive association between the serum DCA concentration and colorectal adenoma as described previously results from the DCA fraction that is absorbed from the colon. This further supports a pathogenic role of DCA in the carcinogenesis of colorectal cancer.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><pmid>7883228</pmid><doi>10.1136/gut.36.2.268</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenoma - blood Bile Acids and Salts - blood Biological and medical sciences Cocarcinogenesis Colorectal Neoplasms - blood Colorectal Neoplasms - etiology Deoxycholic Acid - blood Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Middle Aged Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Unconjugated secondary bile acids in the serum of patients with colorectal adenomas |
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