Potentiation of the hypoglycaemic response to glipizide in diabetic patients by histamine H2‐receptor antagonists

In a randomised placebo controlled study, two groups of six maturity onset diabetic patients stabilised on glipizide were given cimetidine (400 mg) or ranitidine (150 mg) 3 h before a standardised meal. In comparison with placebo, both cimetidine and ranitidine significantly reduced the post‐prandia...

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