Potentiation of the hypoglycaemic response to glipizide in diabetic patients by histamine H2‐receptor antagonists
In a randomised placebo controlled study, two groups of six maturity onset diabetic patients stabilised on glipizide were given cimetidine (400 mg) or ranitidine (150 mg) 3 h before a standardised meal. In comparison with placebo, both cimetidine and ranitidine significantly reduced the post‐prandia...
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| Veröffentlicht in: | British journal of clinical pharmacology 1993-03, Vol.35 (3), p.321-323 |
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| container_title | British journal of clinical pharmacology |
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| creator | Feely, J. Collins, WC Cullen, M. el Debani, AH MacWalter, RS Peden, NR Stevenson, IH |
| description | In a randomised placebo controlled study, two groups of six maturity onset diabetic patients stabilised on glipizide were given cimetidine (400 mg) or ranitidine (150 mg) 3 h before a standardised meal. In comparison with placebo, both cimetidine and ranitidine significantly reduced the post‐prandial rise in blood glucose by a mean of 40% and 25% respectively producing glucose levels of less than 3 mmol l‐1 (lowest 1.5 mmol l‐1) in four patients. Both drugs also significantly increased plasma glipizide AUC by approximately 20%. Caution should be exercised when initiating treatment with H2‐receptor antagonists in diabetics receiving sulphonylurea hypoglycaemic agents. |
| doi_str_mv | 10.1111/j.1365-2125.1993.tb05702.x |
| format | Article |
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In comparison with placebo, both cimetidine and ranitidine significantly reduced the post‐prandial rise in blood glucose by a mean of 40% and 25% respectively producing glucose levels of less than 3 mmol l‐1 (lowest 1.5 mmol l‐1) in four patients. Both drugs also significantly increased plasma glipizide AUC by approximately 20%. Caution should be exercised when initiating treatment with H2‐receptor antagonists in diabetics receiving sulphonylurea hypoglycaemic agents.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.1993.tb05702.x</identifier><identifier>PMID: 8471413</identifier><identifier>CODEN: BCPHBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Biological and medical sciences ; Blood Glucose - analysis ; Cimetidine - pharmacology ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - drug therapy ; Drug Synergism ; Glipizide - blood ; Glipizide - pharmacology ; Glipizide - therapeutic use ; Hormones. Endocrine system ; Humans ; Medical sciences ; Middle Aged ; Pharmacology. 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In comparison with placebo, both cimetidine and ranitidine significantly reduced the post‐prandial rise in blood glucose by a mean of 40% and 25% respectively producing glucose levels of less than 3 mmol l‐1 (lowest 1.5 mmol l‐1) in four patients. Both drugs also significantly increased plasma glipizide AUC by approximately 20%. Caution should be exercised when initiating treatment with H2‐receptor antagonists in diabetics receiving sulphonylurea hypoglycaemic agents.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Cimetidine - pharmacology</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Drug Synergism</subject><subject>Glipizide - blood</subject><subject>Glipizide - pharmacology</subject><subject>Glipizide - therapeutic use</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. 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Endocrine system</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. 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In comparison with placebo, both cimetidine and ranitidine significantly reduced the post‐prandial rise in blood glucose by a mean of 40% and 25% respectively producing glucose levels of less than 3 mmol l‐1 (lowest 1.5 mmol l‐1) in four patients. Both drugs also significantly increased plasma glipizide AUC by approximately 20%. Caution should be exercised when initiating treatment with H2‐receptor antagonists in diabetics receiving sulphonylurea hypoglycaemic agents.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8471413</pmid><doi>10.1111/j.1365-2125.1993.tb05702.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 1993-03, Vol.35 (3), p.321-323 |
| issn | 0306-5251 1365-2125 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Biological and medical sciences Blood Glucose - analysis Cimetidine - pharmacology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Drug Synergism Glipizide - blood Glipizide - pharmacology Glipizide - therapeutic use Hormones. Endocrine system Humans Medical sciences Middle Aged Pharmacology. Drug treatments Ranitidine - pharmacology |
| title | Potentiation of the hypoglycaemic response to glipizide in diabetic patients by histamine H2‐receptor antagonists |
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