Debrisoquine oxidation phenotype and susceptibility to lung cancer

1. It has been suggested that poor metabolisers of debrisoquine are at reduced risk of developing lung cancer from smoking cigarettes. This has been investigated in 82 patients with established cancer of the lung. 2. The frequency of poor metaboliser subjects was not different from that in the norma...

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Veröffentlicht in:	British journal of clinical pharmacology 1990-01, Vol.29 (1), p.101-109
Hauptverfasser:	Speirs, CJ, Murray, S, Davies, DS, Mabadeje, Biola AF, Boobis, AR
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - chemically induced Adenocarcinoma - metabolism Aged Aged, 80 and over Biological and medical sciences Carcinoma, Small Cell - chemically induced Carcinoma, Small Cell - metabolism Carcinoma, Squamous Cell - chemically induced Carcinoma, Squamous Cell - metabolism Debrisoquin - analogs & derivatives Debrisoquin - metabolism Debrisoquin - urine Female General pharmacology Humans Isoquinolines - metabolism Lung Neoplasms - chemically induced Lung Neoplasms - metabolism Male Medical sciences Middle Aged Oxidation-Reduction Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Phenotype Risk Smoking - metabolism
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