Evaluation of the gastric absorption and emptying of drugs under various pH conditions using a simple intubation method: application to diclofenac

Sodium diclofenac (50 mg) together with [14 C]‐PEG as a non‐absorbable marker were dissolved in 400 ml of water (A), phosphate buffer pH 7.5 (B) or a homogenized meal (C). Each of these was ingested in random order by six volunteers on 3 consecutive days. Some gastric absorption of the drug was esta...

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Veröffentlicht in:	British journal of clinical pharmacology 1989-07, Vol.28 (1), p.121-124
Hauptverfasser:	Vidon, N, Pfeiffer, A, Godbillon, J, Rongier, M, Gauron, S, Hirtz, J, Bernier, JJ, Dubois, JP
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Analgesics Biological and medical sciences Chromatography, High Pressure Liquid Diclofenac - administration & dosage Diclofenac - pharmacokinetics Gastric Emptying - drug effects Gastric Mucosa - metabolism Half-Life Humans Hydrogen-Ion Concentration Intubation, Gastrointestinal Medical sciences Neuropharmacology Pharmacology. Drug treatments
Online-Zugang:	Volltext
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