Serum binding of nifedipine and verapamil in patients with ischaemic heart disease on monotherapy
Serum free fractions of nifedipine, verapamil and some of their metabolites were measured in patients with ischaemic heart disease receiving single oral dose and chronic monotherapy and were compared with those obtained in vitro. The percentages of unbound nifedipine and verapamil in vitro (concentr...
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| Veröffentlicht in: | British journal of clinical pharmacology 1989-09, Vol.28 (3), p.357-361 |
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| container_title | British journal of clinical pharmacology |
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| creator | Rumiantsev, DO Piotrovskii, VK Metelitsa, VI Slastnikova, ID Martsevich Yu, S. Kokurina, EV |
| description | Serum free fractions of nifedipine, verapamil and some of their metabolites were measured in patients with ischaemic heart disease receiving single oral dose and chronic monotherapy and were compared with those obtained in vitro. The percentages of unbound nifedipine and verapamil in vitro (concentration range 50‐200 and 150‐400 ng ml‐1, respectively) were 2.51 and 7.23%, respectively, and did not differ from those found on monotherapy with these drugs (2.05 and 8.08%, respectively), and after single dosing. It is suggested that, during treatment with nifedipine or verapamil, their serum metabolites do not affect binding of the parent drugs to serum proteins. |
| doi_str_mv | 10.1111/j.1365-2125.1989.tb05438.x |
| format | Article |
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The percentages of unbound nifedipine and verapamil in vitro (concentration range 50‐200 and 150‐400 ng ml‐1, respectively) were 2.51 and 7.23%, respectively, and did not differ from those found on monotherapy with these drugs (2.05 and 8.08%, respectively), and after single dosing. It is suggested that, during treatment with nifedipine or verapamil, their serum metabolites do not affect binding of the parent drugs to serum proteins.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.1989.tb05438.x</identifier><identifier>PMID: 2789930</identifier><identifier>CODEN: BCPHBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Antianginal agents. Coronary vasodilator agents ; Biological and medical sciences ; Blood Proteins - metabolism ; Cardiovascular system ; Coronary Disease - blood ; Coronary Disease - drug therapy ; Dialysis ; Humans ; Male ; Medical sciences ; Middle Aged ; Nifedipine - blood ; Nifedipine - therapeutic use ; Pharmacology. 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The percentages of unbound nifedipine and verapamil in vitro (concentration range 50‐200 and 150‐400 ng ml‐1, respectively) were 2.51 and 7.23%, respectively, and did not differ from those found on monotherapy with these drugs (2.05 and 8.08%, respectively), and after single dosing. It is suggested that, during treatment with nifedipine or verapamil, their serum metabolites do not affect binding of the parent drugs to serum proteins.</description><subject>Adult</subject><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - metabolism</subject><subject>Cardiovascular system</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - drug therapy</subject><subject>Dialysis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nifedipine - blood</subject><subject>Nifedipine - therapeutic use</subject><subject>Pharmacology. 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Coronary vasodilator agents</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - metabolism</topic><topic>Cardiovascular system</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - drug therapy</topic><topic>Dialysis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nifedipine - blood</topic><topic>Nifedipine - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Binding</topic><topic>Verapamil - blood</topic><topic>Verapamil - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rumiantsev, DO</creatorcontrib><creatorcontrib>Piotrovskii, VK</creatorcontrib><creatorcontrib>Metelitsa, VI</creatorcontrib><creatorcontrib>Slastnikova, ID</creatorcontrib><creatorcontrib>Martsevich Yu, S.</creatorcontrib><creatorcontrib>Kokurina, EV</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rumiantsev, DO</au><au>Piotrovskii, VK</au><au>Metelitsa, VI</au><au>Slastnikova, ID</au><au>Martsevich Yu, S.</au><au>Kokurina, EV</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum binding of nifedipine and verapamil in patients with ischaemic heart disease on monotherapy</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1989-09</date><risdate>1989</risdate><volume>28</volume><issue>3</issue><spage>357</spage><epage>361</epage><pages>357-361</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><coden>BCPHBM</coden><abstract>Serum free fractions of nifedipine, verapamil and some of their metabolites were measured in patients with ischaemic heart disease receiving single oral dose and chronic monotherapy and were compared with those obtained in vitro. The percentages of unbound nifedipine and verapamil in vitro (concentration range 50‐200 and 150‐400 ng ml‐1, respectively) were 2.51 and 7.23%, respectively, and did not differ from those found on monotherapy with these drugs (2.05 and 8.08%, respectively), and after single dosing. It is suggested that, during treatment with nifedipine or verapamil, their serum metabolites do not affect binding of the parent drugs to serum proteins.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2789930</pmid><doi>10.1111/j.1365-2125.1989.tb05438.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 1989-09, Vol.28 (3), p.357-361 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adult Antianginal agents. Coronary vasodilator agents Biological and medical sciences Blood Proteins - metabolism Cardiovascular system Coronary Disease - blood Coronary Disease - drug therapy Dialysis Humans Male Medical sciences Middle Aged Nifedipine - blood Nifedipine - therapeutic use Pharmacology. Drug treatments Protein Binding Verapamil - blood Verapamil - therapeutic use |
| title | Serum binding of nifedipine and verapamil in patients with ischaemic heart disease on monotherapy |
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