Candidate Locus for a Nuclear Modifier Gene for Maternally Inherited Deafness

Maternally inherited deafness associated with the A1555G mutation in the mitochondrial 12S ribosomal RNA (rRNA) gene appears to require additional environmental or genetic changes for phenotypic expression. Aminoglycosides have been identified as one such environmental factor. In one large Arab-Isra...

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Veröffentlicht in:	American journal of human genetics 2000-06, Vol.66 (6), p.1905-1910
Hauptverfasser:	Bykhovskaya, Yelena, Estivill, Xavier, Taylor, Kent, Hang, Tieu, Hamon, Melanie, Casano, Rosaria A.M.S., Yang, Huiying, Rotter, Jerome I., Shohat, Mordechai, Fischel-Ghodsian, Nathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Arabs - genetics Cell Nucleus - genetics Chromosome Mapping DNA, Mitochondrial - genetics Female Genes, Dominant Genes, Recessive Genetic Heterogeneity Genetic Linkage - genetics Genetic Markers - genetics Hearing Loss, Sensorineural - congenital Hearing Loss, Sensorineural - genetics Humans Israel Italy Lod Score Male Matched-Pair Analysis Models, Genetic Mutation - genetics Pedigree Penetrance RNA, Ribosomal - genetics Spain Statistics, Nonparametric
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