Severe Hepatic Fibrosis in Schistosoma mansoni Infection Is Controlled by a Major Locus That Is Closely Linked to the Interferon-γ Receptor Gene

Lethal disease due to hepatic periportal fibrosis occurs in 2%–10% of subjects infected by Schistosoma mansoni in endemic regions such as Sudan. It is unknown why few infected individuals present with severe disease, and inherited factors may play a role in fibrosis development. Schistosoma mansoni...

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Veröffentlicht in:	American journal of human genetics 1999-09, Vol.65 (3), p.709-721
Hauptverfasser:	Dessein, Alain J., Hillaire, Dominique, Elwali, Nasr Eldin M.A., Marquet, Sandrine, Mohamed-Ali, Qurashi, Mirghani, Adil, Henri, Sandrine, Abdelhameed, Ahmed A., Saeed, Osman K., Magzoub, Mubarak M.A., Abel, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Child Chromosomes, Human, Pair 6 - genetics Diseases caused by trematodes Female Genetic Markers Genetic Predisposition to Disease Helminthic diseases Hepatic fibrosis Humans Infectious diseases Interferon gamma Receptor Interferon-γ Life Sciences Liver Cirrhosis - diagnostic imaging Liver Cirrhosis - genetics Liver Cirrhosis - parasitology Liver Diseases, Parasitic - complications Liver Diseases, Parasitic - genetics Liver Diseases, Parasitic - parasitology Lod Score Male Medical sciences Middle Aged Odds Ratio Parasitic diseases Pedigree Penetrance Portal hypertension Receptors, Interferon - genetics Schistosomiases Schistosomiasis Schistosomiasis mansoni - complications Schistosomiasis mansoni - genetics Schistosomiasis mansoni - parasitology Sex Factors Sudan Time Factors Tropical medicine Ultrasonography
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