An Extreme-Sib-Pair Genome Scan for Genes Regulating Blood Pressure
Hypertension, a risk factor for many cardiovascular, cerebrovascular, and renal diseases, affects one in four Americans, at an annual cost of >$30 billion. Although genetic mutations have been identified in rare forms of hypertension, including Liddle syndrome and glucocorticoid-remediable aldost...
Gespeichert in:
| Veröffentlicht in: | American journal of human genetics 1999-06, Vol.64 (6), p.1694-1701 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1701 |
|---|---|
| container_issue | 6 |
| container_start_page | 1694 |
| container_title | American journal of human genetics |
| container_volume | 64 |
| creator | Xu, Xiping Rogus, John J. Terwedow, Henry A. Yang, Jianhua Wang, Zhaoxi Chen, Changzhong Niu, Tianhua Wang, Binyan Xu, Hengqiu Weiss, Scott Schork, Nicholas J. Fang, Zhian |
| description | Hypertension, a risk factor for many cardiovascular, cerebrovascular, and renal diseases, affects one in four Americans, at an annual cost of >$30 billion. Although genetic mutations have been identified in rare forms of hypertension, including Liddle syndrome and glucocorticoid-remediable aldosteronism, the abundance of plausible candidate genes and potential environmental risk factors has complicated the genetic dissection of more prevalent essential hypertension. To search systematically for chromosomal regions containing genes that regulate blood pressure, we scanned the entire autosomal genome by using 367 polymorphic markers. Our study population, selected from a blood-pressure screen of >200,000 Chinese adults, comprises rare but highly efficient extreme sib pairs (207 discordant, 258 high concordant, and 99 low concordant) and all but a single parent of these sibs. By virtue of the sampling design, the number of sib pairs, and the availability of genotyped parents, this study represents one of the most powerful of its kind. Although no regions achieved a 5% genomewide significance level, maximum LOD-score values were >2.0 (unadjusted
P |
| doi_str_mv | 10.1086/302405 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1377913</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002929707636726</els_id><sourcerecordid>69765885</sourcerecordid><originalsourceid>FETCH-LOGICAL-c432t-16770f2d4acfd09176baf8653acac3dab46d2e614204af033e52e90349ca40933</originalsourceid><addsrcrecordid>eNpdkFtr3DAQhUVJabbb9icEP4S8OR1ZtmS9BJIlNwhk6bbPYlYebxVsKZHs0P77ON2luTwNw3ycc-Yw9o3DMYdafhdQlFB9YDNeCZVLCdUemwFAketCq332OaU7AM5rEJ_YPgchQFRqxhanPjv_M0TqKV-5db5EF7NL8qGnbGXRZ234t1PKftBm7HBwfpOddSE02TJSSmOkL-xji12ir7s5Z78uzn8urvKb28vrxelNbktRDDmXSkFbNCXatgHNlVxjW8tKoEUrGlyXsilI8rKAEtspIVUFaRCltliCFmLOTra69-O6p8aSHyJ25j66HuNfE9CZtxfvfptNeDRcKKX5s8DRTiCGh5HSYHqXLHUdegpjMlIrWdV19QLaGFKK1P434WCe-zbbvifw4HWkV9i24Ak43AGYLHZtRG9deuF0zeX045zBFqOpv0dH0STryFtqXCQ7mCa499ZPD7qWMg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69765885</pqid></control><display><type>article</type><title>An Extreme-Sib-Pair Genome Scan for Genes Regulating Blood Pressure</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ScienceDirect Journals (5 years ago - present)</source><source>PubMed Central</source><creator>Xu, Xiping ; Rogus, John J. ; Terwedow, Henry A. ; Yang, Jianhua ; Wang, Zhaoxi ; Chen, Changzhong ; Niu, Tianhua ; Wang, Binyan ; Xu, Hengqiu ; Weiss, Scott ; Schork, Nicholas J. ; Fang, Zhian</creator><creatorcontrib>Xu, Xiping ; Rogus, John J. ; Terwedow, Henry A. ; Yang, Jianhua ; Wang, Zhaoxi ; Chen, Changzhong ; Niu, Tianhua ; Wang, Binyan ; Xu, Hengqiu ; Weiss, Scott ; Schork, Nicholas J. ; Fang, Zhian</creatorcontrib><description>Hypertension, a risk factor for many cardiovascular, cerebrovascular, and renal diseases, affects one in four Americans, at an annual cost of >$30 billion. Although genetic mutations have been identified in rare forms of hypertension, including Liddle syndrome and glucocorticoid-remediable aldosteronism, the abundance of plausible candidate genes and potential environmental risk factors has complicated the genetic dissection of more prevalent essential hypertension. To search systematically for chromosomal regions containing genes that regulate blood pressure, we scanned the entire autosomal genome by using 367 polymorphic markers. Our study population, selected from a blood-pressure screen of >200,000 Chinese adults, comprises rare but highly efficient extreme sib pairs (207 discordant, 258 high concordant, and 99 low concordant) and all but a single parent of these sibs. By virtue of the sampling design, the number of sib pairs, and the availability of genotyped parents, this study represents one of the most powerful of its kind. Although no regions achieved a 5% genomewide significance level, maximum LOD-score values were >2.0 (unadjusted
P<.001) for regions containing five markers (
D3S2387, D11S2019, D15S657, D16S3396, and
D17S1303), in our primary analysis. Other promising regions identified through secondary analyses include loci near
D4S3248, D7S2195, D10S1423, D20S470, D20S482, D21S2052, PAH, and
AGT.</description><identifier>ISSN: 0002-9297</identifier><identifier>EISSN: 1537-6605</identifier><identifier>DOI: 10.1086/302405</identifier><identifier>PMID: 10330357</identifier><identifier>CODEN: AJHGAG</identifier><language>eng</language><publisher>Chicago, IL: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - genetics ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Genome ; Genome scan ; Humans ; Hypertension ; Medical sciences ; Nuclear Family ; Sib pairs</subject><ispartof>American journal of human genetics, 1999-06, Vol.64 (6), p.1694-1701</ispartof><rights>1999 The American Society of Human Genetics</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-16770f2d4acfd09176baf8653acac3dab46d2e614204af033e52e90349ca40933</citedby><cites>FETCH-LOGICAL-c432t-16770f2d4acfd09176baf8653acac3dab46d2e614204af033e52e90349ca40933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1377913/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1086/302405$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3550,27924,27925,45995,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1981690$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10330357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Xiping</creatorcontrib><creatorcontrib>Rogus, John J.</creatorcontrib><creatorcontrib>Terwedow, Henry A.</creatorcontrib><creatorcontrib>Yang, Jianhua</creatorcontrib><creatorcontrib>Wang, Zhaoxi</creatorcontrib><creatorcontrib>Chen, Changzhong</creatorcontrib><creatorcontrib>Niu, Tianhua</creatorcontrib><creatorcontrib>Wang, Binyan</creatorcontrib><creatorcontrib>Xu, Hengqiu</creatorcontrib><creatorcontrib>Weiss, Scott</creatorcontrib><creatorcontrib>Schork, Nicholas J.</creatorcontrib><creatorcontrib>Fang, Zhian</creatorcontrib><title>An Extreme-Sib-Pair Genome Scan for Genes Regulating Blood Pressure</title><title>American journal of human genetics</title><addtitle>Am J Hum Genet</addtitle><description>Hypertension, a risk factor for many cardiovascular, cerebrovascular, and renal diseases, affects one in four Americans, at an annual cost of >$30 billion. Although genetic mutations have been identified in rare forms of hypertension, including Liddle syndrome and glucocorticoid-remediable aldosteronism, the abundance of plausible candidate genes and potential environmental risk factors has complicated the genetic dissection of more prevalent essential hypertension. To search systematically for chromosomal regions containing genes that regulate blood pressure, we scanned the entire autosomal genome by using 367 polymorphic markers. Our study population, selected from a blood-pressure screen of >200,000 Chinese adults, comprises rare but highly efficient extreme sib pairs (207 discordant, 258 high concordant, and 99 low concordant) and all but a single parent of these sibs. By virtue of the sampling design, the number of sib pairs, and the availability of genotyped parents, this study represents one of the most powerful of its kind. Although no regions achieved a 5% genomewide significance level, maximum LOD-score values were >2.0 (unadjusted
P<.001) for regions containing five markers (
D3S2387, D11S2019, D15S657, D16S3396, and
D17S1303), in our primary analysis. Other promising regions identified through secondary analyses include loci near
D4S3248, D7S2195, D10S1423, D20S470, D20S482, D21S2052, PAH, and
AGT.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - genetics</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Genome</subject><subject>Genome scan</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Medical sciences</subject><subject>Nuclear Family</subject><subject>Sib pairs</subject><issn>0002-9297</issn><issn>1537-6605</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkFtr3DAQhUVJabbb9icEP4S8OR1ZtmS9BJIlNwhk6bbPYlYebxVsKZHs0P77ON2luTwNw3ycc-Yw9o3DMYdafhdQlFB9YDNeCZVLCdUemwFAketCq332OaU7AM5rEJ_YPgchQFRqxhanPjv_M0TqKV-5db5EF7NL8qGnbGXRZ234t1PKftBm7HBwfpOddSE02TJSSmOkL-xji12ir7s5Z78uzn8urvKb28vrxelNbktRDDmXSkFbNCXatgHNlVxjW8tKoEUrGlyXsilI8rKAEtspIVUFaRCltliCFmLOTra69-O6p8aSHyJ25j66HuNfE9CZtxfvfptNeDRcKKX5s8DRTiCGh5HSYHqXLHUdegpjMlIrWdV19QLaGFKK1P434WCe-zbbvifw4HWkV9i24Ak43AGYLHZtRG9deuF0zeX045zBFqOpv0dH0STryFtqXCQ7mCa499ZPD7qWMg</recordid><startdate>19990601</startdate><enddate>19990601</enddate><creator>Xu, Xiping</creator><creator>Rogus, John J.</creator><creator>Terwedow, Henry A.</creator><creator>Yang, Jianhua</creator><creator>Wang, Zhaoxi</creator><creator>Chen, Changzhong</creator><creator>Niu, Tianhua</creator><creator>Wang, Binyan</creator><creator>Xu, Hengqiu</creator><creator>Weiss, Scott</creator><creator>Schork, Nicholas J.</creator><creator>Fang, Zhian</creator><general>Elsevier Inc</general><general>University of Chicago Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19990601</creationdate><title>An Extreme-Sib-Pair Genome Scan for Genes Regulating Blood Pressure</title><author>Xu, Xiping ; Rogus, John J. ; Terwedow, Henry A. ; Yang, Jianhua ; Wang, Zhaoxi ; Chen, Changzhong ; Niu, Tianhua ; Wang, Binyan ; Xu, Hengqiu ; Weiss, Scott ; Schork, Nicholas J. ; Fang, Zhian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-16770f2d4acfd09176baf8653acac3dab46d2e614204af033e52e90349ca40933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - genetics</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Genome</topic><topic>Genome scan</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Medical sciences</topic><topic>Nuclear Family</topic><topic>Sib pairs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Xiping</creatorcontrib><creatorcontrib>Rogus, John J.</creatorcontrib><creatorcontrib>Terwedow, Henry A.</creatorcontrib><creatorcontrib>Yang, Jianhua</creatorcontrib><creatorcontrib>Wang, Zhaoxi</creatorcontrib><creatorcontrib>Chen, Changzhong</creatorcontrib><creatorcontrib>Niu, Tianhua</creatorcontrib><creatorcontrib>Wang, Binyan</creatorcontrib><creatorcontrib>Xu, Hengqiu</creatorcontrib><creatorcontrib>Weiss, Scott</creatorcontrib><creatorcontrib>Schork, Nicholas J.</creatorcontrib><creatorcontrib>Fang, Zhian</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Xiping</au><au>Rogus, John J.</au><au>Terwedow, Henry A.</au><au>Yang, Jianhua</au><au>Wang, Zhaoxi</au><au>Chen, Changzhong</au><au>Niu, Tianhua</au><au>Wang, Binyan</au><au>Xu, Hengqiu</au><au>Weiss, Scott</au><au>Schork, Nicholas J.</au><au>Fang, Zhian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Extreme-Sib-Pair Genome Scan for Genes Regulating Blood Pressure</atitle><jtitle>American journal of human genetics</jtitle><addtitle>Am J Hum Genet</addtitle><date>1999-06-01</date><risdate>1999</risdate><volume>64</volume><issue>6</issue><spage>1694</spage><epage>1701</epage><pages>1694-1701</pages><issn>0002-9297</issn><eissn>1537-6605</eissn><coden>AJHGAG</coden><abstract>Hypertension, a risk factor for many cardiovascular, cerebrovascular, and renal diseases, affects one in four Americans, at an annual cost of >$30 billion. Although genetic mutations have been identified in rare forms of hypertension, including Liddle syndrome and glucocorticoid-remediable aldosteronism, the abundance of plausible candidate genes and potential environmental risk factors has complicated the genetic dissection of more prevalent essential hypertension. To search systematically for chromosomal regions containing genes that regulate blood pressure, we scanned the entire autosomal genome by using 367 polymorphic markers. Our study population, selected from a blood-pressure screen of >200,000 Chinese adults, comprises rare but highly efficient extreme sib pairs (207 discordant, 258 high concordant, and 99 low concordant) and all but a single parent of these sibs. By virtue of the sampling design, the number of sib pairs, and the availability of genotyped parents, this study represents one of the most powerful of its kind. Although no regions achieved a 5% genomewide significance level, maximum LOD-score values were >2.0 (unadjusted
P<.001) for regions containing five markers (
D3S2387, D11S2019, D15S657, D16S3396, and
D17S1303), in our primary analysis. Other promising regions identified through secondary analyses include loci near
D4S3248, D7S2195, D10S1423, D20S470, D20S482, D21S2052, PAH, and
AGT.</abstract><cop>Chicago, IL</cop><pub>Elsevier Inc</pub><pmid>10330357</pmid><doi>10.1086/302405</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9297 |
| ispartof | American journal of human genetics, 1999-06, Vol.64 (6), p.1694-1701 |
| issn | 0002-9297 1537-6605 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1377913 |
| source | MEDLINE; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); PubMed Central |
| subjects | Adolescent Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - genetics Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Genome Genome scan Humans Hypertension Medical sciences Nuclear Family Sib pairs |
| title | An Extreme-Sib-Pair Genome Scan for Genes Regulating Blood Pressure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T20%3A14%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20Extreme-Sib-Pair%20Genome%20Scan%20for%20Genes%20Regulating%20Blood%20Pressure&rft.jtitle=American%20journal%20of%20human%20genetics&rft.au=Xu,%20Xiping&rft.date=1999-06-01&rft.volume=64&rft.issue=6&rft.spage=1694&rft.epage=1701&rft.pages=1694-1701&rft.issn=0002-9297&rft.eissn=1537-6605&rft.coden=AJHGAG&rft_id=info:doi/10.1086/302405&rft_dat=%3Cproquest_pubme%3E69765885%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69765885&rft_id=info:pmid/10330357&rft_els_id=S0002929707636726&rfr_iscdi=true |