Quantitative-Trait Locus for Specific Language and Reading Deficits on Chromosome 6p
Reading disability (RD), or dyslexia, is a complex cognitive disorder manifested by difficulties in learning to read, in otherwise normal individuals. Individuals with RD manifest deficits in several reading and language skills. Previous research has suggested the existence of a quantitative-trait l...
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| Veröffentlicht in: | American journal of human genetics 1999, Vol.64 (1), p.157-164 |
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| creator | Gayán, Javier Smith, Shelley D. Cherny, Stacey S. Cardon, Lon R. Fulker, David W. Brower, Amy M. Olson, Richard K. Pennington, Bruce F. DeFries, John C. |
| description | Reading disability (RD), or dyslexia, is a complex cognitive disorder manifested by difficulties in learning to read, in otherwise normal individuals. Individuals with RD manifest deficits in several reading and language skills. Previous research has suggested the existence of a quantitative-trait locus (QTL) for RD on the short arm of chromosome 6. In the present study, RD subjects' performance in several measures of word recognition and component skills of orthographic coding, phonological decoding, and phoneme awareness were individually subjected to QTL analysis, with a new sample of 126 sib pairs, by means of a multipoint mapping method and eight informative DNA markers on chromosome 6 (D6S461, D6S276, D6S105, D6S306, D6S258, D6S439, D6S291, and D6S1019). The results indicate significant linkage across a distance of at least 5 cM for deficits in orthographic (LOD = 3.10) and phonological (LOD = 2.42) skills, confirming previous findings. |
| doi_str_mv | 10.1086/302191 |
| format | Article |
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Individuals with RD manifest deficits in several reading and language skills. Previous research has suggested the existence of a quantitative-trait locus (QTL) for RD on the short arm of chromosome 6. In the present study, RD subjects' performance in several measures of word recognition and component skills of orthographic coding, phonological decoding, and phoneme awareness were individually subjected to QTL analysis, with a new sample of 126 sib pairs, by means of a multipoint mapping method and eight informative DNA markers on chromosome 6 (D6S461, D6S276, D6S105, D6S306, D6S258, D6S439, D6S291, and D6S1019). The results indicate significant linkage across a distance of at least 5 cM for deficits in orthographic (LOD = 3.10) and phonological (LOD = 2.42) skills, confirming previous findings.</description><identifier>ISSN: 0002-9297</identifier><identifier>EISSN: 1537-6605</identifier><identifier>DOI: 10.1086/302191</identifier><identifier>PMID: 9915954</identifier><identifier>CODEN: AJHGAG</identifier><language>eng</language><publisher>Chicago, IL: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Child ; Child clinical studies ; Chromosomes, Human, Pair 6 ; Developmental disorders ; Dyslexia ; Dyslexia - genetics ; Female ; Genetic Markers ; Humans ; Language Development Disorders - genetics ; Learning disorders ; Linkage ; Lod Score ; Male ; Medical sciences ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Quantitative trait loci ; Quantitative Trait, Heritable ; Reading disability ; Twins</subject><ispartof>American journal of human genetics, 1999, Vol.64 (1), p.157-164</ispartof><rights>1999 The American Society of Human Genetics</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-4328665ee5aa599f634866ed97da0a1bbf3f256aec38b6d59a6400a33d20cd2a3</citedby><cites>FETCH-LOGICAL-c431t-4328665ee5aa599f634866ed97da0a1bbf3f256aec38b6d59a6400a33d20cd2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1377713/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002929707616681$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,3537,4010,27900,27901,27902,53766,53768,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1682670$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9915954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gayán, Javier</creatorcontrib><creatorcontrib>Smith, Shelley D.</creatorcontrib><creatorcontrib>Cherny, Stacey S.</creatorcontrib><creatorcontrib>Cardon, Lon R.</creatorcontrib><creatorcontrib>Fulker, David W.</creatorcontrib><creatorcontrib>Brower, Amy M.</creatorcontrib><creatorcontrib>Olson, Richard K.</creatorcontrib><creatorcontrib>Pennington, Bruce F.</creatorcontrib><creatorcontrib>DeFries, John C.</creatorcontrib><title>Quantitative-Trait Locus for Specific Language and Reading Deficits on Chromosome 6p</title><title>American journal of human genetics</title><addtitle>Am J Hum Genet</addtitle><description>Reading disability (RD), or dyslexia, is a complex cognitive disorder manifested by difficulties in learning to read, in otherwise normal individuals. Individuals with RD manifest deficits in several reading and language skills. Previous research has suggested the existence of a quantitative-trait locus (QTL) for RD on the short arm of chromosome 6. In the present study, RD subjects' performance in several measures of word recognition and component skills of orthographic coding, phonological decoding, and phoneme awareness were individually subjected to QTL analysis, with a new sample of 126 sib pairs, by means of a multipoint mapping method and eight informative DNA markers on chromosome 6 (D6S461, D6S276, D6S105, D6S306, D6S258, D6S439, D6S291, and D6S1019). The results indicate significant linkage across a distance of at least 5 cM for deficits in orthographic (LOD = 3.10) and phonological (LOD = 2.42) skills, confirming previous findings.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Chromosomes, Human, Pair 6</subject><subject>Developmental disorders</subject><subject>Dyslexia</subject><subject>Dyslexia - genetics</subject><subject>Female</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>Language Development Disorders - genetics</subject><subject>Learning disorders</subject><subject>Linkage</subject><subject>Lod Score</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Quantitative trait loci</subject><subject>Quantitative Trait, Heritable</subject><subject>Reading disability</subject><subject>Twins</subject><issn>0002-9297</issn><issn>1537-6605</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkNFqFDEUhoNY6trqGwi5EO_GJpNJZnJTkFVbYUHartfhbHJmmzKTrElmoW_vyC6t9upw-D_-c_gIec_ZZ846dSFYzTV_RRZcirZSisnXZMEYqytd6_YNeZvzA2Ocd0ycklOtudSyWZD1zQSh-ALF77FaJ_CFrqKdMu1jonc7tL73lq4gbCfYIoXg6C2C82FLv-Ic-ZJpDHR5n-IYcxyRqt05OelhyPjuOM_Ir-_f1svravXz6sfyy6qyjeClakTdKSURJYDUuleimXd0unXAgG82vehrqQCt6DbKSQ2qYQyEcDWzrgZxRi4PvbtpM6KzGEqCweySHyE9mgje_J8Ef2-2cW-4aNuWi7ng07Egxd8T5mJGny0OAwSMUzZKSymVbJ5Bm2LOCfunI5yZv_7Nwf8Mfvj3pSfsKHzOPx5zyBaGPkGwPj-3qa5WLZsxdsBw1rf3mEy2HoNF5xPaYlz0Ly__AUQ8nQE</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>Gayán, Javier</creator><creator>Smith, Shelley D.</creator><creator>Cherny, Stacey S.</creator><creator>Cardon, Lon R.</creator><creator>Fulker, David W.</creator><creator>Brower, Amy M.</creator><creator>Olson, Richard K.</creator><creator>Pennington, Bruce F.</creator><creator>DeFries, John C.</creator><general>Elsevier Inc</general><general>University of Chicago Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>1999</creationdate><title>Quantitative-Trait Locus for Specific Language and Reading Deficits on Chromosome 6p</title><author>Gayán, Javier ; Smith, Shelley D. ; Cherny, Stacey S. ; Cardon, Lon R. ; Fulker, David W. ; Brower, Amy M. ; Olson, Richard K. ; Pennington, Bruce F. ; DeFries, John C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-4328665ee5aa599f634866ed97da0a1bbf3f256aec38b6d59a6400a33d20cd2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>Chromosomes, Human, Pair 6</topic><topic>Developmental disorders</topic><topic>Dyslexia</topic><topic>Dyslexia - genetics</topic><topic>Female</topic><topic>Genetic Markers</topic><topic>Humans</topic><topic>Language Development Disorders - genetics</topic><topic>Learning disorders</topic><topic>Linkage</topic><topic>Lod Score</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Quantitative trait loci</topic><topic>Quantitative Trait, Heritable</topic><topic>Reading disability</topic><topic>Twins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gayán, Javier</creatorcontrib><creatorcontrib>Smith, Shelley D.</creatorcontrib><creatorcontrib>Cherny, Stacey S.</creatorcontrib><creatorcontrib>Cardon, Lon R.</creatorcontrib><creatorcontrib>Fulker, David W.</creatorcontrib><creatorcontrib>Brower, Amy M.</creatorcontrib><creatorcontrib>Olson, Richard K.</creatorcontrib><creatorcontrib>Pennington, Bruce F.</creatorcontrib><creatorcontrib>DeFries, John C.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gayán, Javier</au><au>Smith, Shelley D.</au><au>Cherny, Stacey S.</au><au>Cardon, Lon R.</au><au>Fulker, David W.</au><au>Brower, Amy M.</au><au>Olson, Richard K.</au><au>Pennington, Bruce F.</au><au>DeFries, John C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative-Trait Locus for Specific Language and Reading Deficits on Chromosome 6p</atitle><jtitle>American journal of human genetics</jtitle><addtitle>Am J Hum Genet</addtitle><date>1999</date><risdate>1999</risdate><volume>64</volume><issue>1</issue><spage>157</spage><epage>164</epage><pages>157-164</pages><issn>0002-9297</issn><eissn>1537-6605</eissn><coden>AJHGAG</coden><abstract>Reading disability (RD), or dyslexia, is a complex cognitive disorder manifested by difficulties in learning to read, in otherwise normal individuals. Individuals with RD manifest deficits in several reading and language skills. Previous research has suggested the existence of a quantitative-trait locus (QTL) for RD on the short arm of chromosome 6. In the present study, RD subjects' performance in several measures of word recognition and component skills of orthographic coding, phonological decoding, and phoneme awareness were individually subjected to QTL analysis, with a new sample of 126 sib pairs, by means of a multipoint mapping method and eight informative DNA markers on chromosome 6 (D6S461, D6S276, D6S105, D6S306, D6S258, D6S439, D6S291, and D6S1019). The results indicate significant linkage across a distance of at least 5 cM for deficits in orthographic (LOD = 3.10) and phonological (LOD = 2.42) skills, confirming previous findings.</abstract><cop>Chicago, IL</cop><pub>Elsevier Inc</pub><pmid>9915954</pmid><doi>10.1086/302191</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological and medical sciences Child Child clinical studies Chromosomes, Human, Pair 6 Developmental disorders Dyslexia Dyslexia - genetics Female Genetic Markers Humans Language Development Disorders - genetics Learning disorders Linkage Lod Score Male Medical sciences Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Quantitative trait loci Quantitative Trait, Heritable Reading disability Twins |
| title | Quantitative-Trait Locus for Specific Language and Reading Deficits on Chromosome 6p |
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