Primary Autosomal Recessive Microcephaly (MCPH1) Maps to Chromosome 8p22-pter

Primary (or “true”) microcephaly is inherited as an autosomal recessive trait and is thought to be genetically heterogeneous. Using autozygosity mapping, we have identified a genetic locus (MCPH1) for primary microcephaly, at chromosome 8p22-pter, in two consanguineous families of Pakistani origin....

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