Mitogen-Activated Protein Kinases Control Cardiac KChIP2 Gene Expression

Hypertrophied myocardium is associated with reductions in the transient outward K current (Ito) and expression of pore-forming Kv4.2/4.3 and auxiliary KChIP2 subunits. Here we show that KChIP2 mRNA and protein levels are dramatically decreased to 10% to 30% of control levels in the left ventricle of...

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Veröffentlicht in:	Circulation research 2006-02, Vol.98 (3), p.386-393
Hauptverfasser:	Jia, Ying, Takimoto, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Cells, Cultured Fundamental and applied biological sciences. Psychology Gene Expression Regulation Heart Ventricles - cytology Heart Ventricles - drug effects Kv Channel-Interacting Proteins - genetics Male Mitogen-Activated Protein Kinases - metabolism Muscle Cells - drug effects Muscle Cells - physiology Patch-Clamp Techniques Phenylephrine - pharmacology Rats Rats, Sprague-Dawley RNA, Messenger - genetics Ventricular Function Vertebrates: cardiovascular system
Online-Zugang:	Volltext
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