The selenocysteine incorporation machinery: Interactions between the SECIS RNA and the SECIS-binding protein SBP2

The decoding of UGA as a selenocysteine (Sec) codon in mammalian selenoprotein mRNAs requires a selenocysteine insertion sequence (SECIS) element in the 3′ untranslated region. The SECIS is a hairpin structure that contains a non-Watson–Crick base-pair quartet with a conserved G.A/A.G tandem in the...

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Veröffentlicht in:	RNA (Cambridge) 2001-10, Vol.7 (10), p.1442-1453
Hauptverfasser:	FLETCHER, JULIA E., COPELAND, PAUL R., DRISCOLL, DONNA M., KROL, ALAIN
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Pairing Base Sequence DNA Primers DNA-Binding Proteins - metabolism Humans Mice Models, Molecular Nucleic Acid Conformation Rats Recombinant Proteins - metabolism RNA - chemistry RNA - metabolism RNA-Binding Proteins SBP2 protein SECIS-binding protein Selenocysteine - metabolism selenoproteins
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