X-ray crystallographic observation of “in-line” and “adjacent” conformations in a bulged self-cleaving RNA/DNA hybrid

The RNA strand in an RNA/DNA duplex with unpaired ribonucleotides can undergo self-cleavage at bulge sites in the presence of a variety of divalent metal ions (Hüsken et al., Biochemistry, 1996, 35:16591–16600). Transesterification proceeds via an in-line mechanism, with the 2′-OH of the bulged nucl...

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Veröffentlicht in:	RNA (Cambridge) 2001-03, Vol.7 (3), p.405-420, Article S1355838201001935
Hauptverfasser:	TERESHKO, VALENTINA, WALLACE, SCOT T., USMAN, NASSIM, WINCOTT, FRANCINE E., EGLI, MARTIN
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - chemistry Crystallography, X-Ray DNA, Catalytic - chemistry DNA, Catalytic - metabolism Hydrogen Bonding Models, Molecular Nucleic Acid Conformation Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Oligoribonucleotides - chemistry Oligoribonucleotides - metabolism RNA, Catalytic - chemistry RNA, Catalytic - metabolism Spermidine - chemistry Spermine - chemistry
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