Two alternating structures of the HIV-1 leader RNA

In this study we demonstrate that the HIV-1 leader RNA exists in two alternative conformations, a branched structure consisting of several well-known hairpin motifs and a more stable structure that is formed by extensive long-distance base pairing. The latter conformation was first identified as a c...

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Veröffentlicht in:	RNA (Cambridge) 2001-01, Vol.7 (1), p.143-157, Article S1355838201001881
Hauptverfasser:	HUTHOFF, HENDRIK, BERKHOUT, BEN
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Base Sequence dimer initiation site Dimerization HIV-1 - genetics Hot Temperature Human immunodeficiency virus 1 Humans leader RNA Models, Molecular Molecular Sequence Data Mutagenesis Nucleic Acid Conformation Nucleic Acid Denaturation nucleocapsid protein Poly A Proviruses - genetics RNA, Spliced Leader - chemistry RNA, Spliced Leader - genetics RNA, Viral - chemistry RNA, Viral - genetics Sequence Deletion Thermodynamics
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