Identification of a MAD2-binding protein, CMT2, and its role in mitosis

MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. It binds to human p55CDC and prevents it from promoting destruction of an anaphase inhibitor, securin. Here we report the characterization of a novel MAD2‐bindi...

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Veröffentlicht in:	The EMBO journal 2002-12, Vol.21 (23), p.6419-6428
Hauptverfasser:	Habu, Toshiyuki, Kim, Sang Hoon, Weinstein, Jasminder, Matsumoto, Tomohiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Calcium-Binding Proteins - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cdc20 Proteins Cell Cycle - physiology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism CMT2 EMBO06 Fungal Proteins - metabolism HeLa Cells Humans MAD2 Mad2 Proteins Mice mitosis Mitosis - physiology Molecular Sequence Data Nuclear Proteins Proteins - metabolism Sequence Alignment Spindle Apparatus - metabolism spindle checkpoint
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