Control of myelination in Schwann cells: a Krox20 cis-regulatory element integrates Oct6, Brn2 and Sox10 activities

Myelination in Schwann cells is governed by several transcription factors, including the POU proteins Oct6 and Brn2, the high mobility group protein Sox10 and the zinc‐finger protein Krox20. How the function of these factors is integrated in the control of myelination has not been established. Previ...

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Veröffentlicht in:	EMBO reports 2006-01, Vol.7 (1), p.52-58
Hauptverfasser:	Ghislain, Julien, Charnay, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Brn2/N-Oct-3/Pou3f2/Oft-7 Chickens DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Early Growth Response Protein 2 - genetics Early Growth Response Protein 2 - metabolism Enhancer Elements, Genetic Gene Expression Regulation HeLa Cells High Mobility Group Proteins - genetics High Mobility Group Proteins - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Krox20/Egr2 Mice Molecular Sequence Data Mutation Myelin Sheath - metabolism myelination Oct6/Tst1/SCIP/Pou3f1/Oft-6 Organic Cation Transport Proteins - genetics Organic Cation Transport Proteins - metabolism peripheral nervous system POU Domain Factors - genetics POU Domain Factors - metabolism Proteins Schwann Cells - cytology Schwann Cells - metabolism Scientific Report Sequence Alignment SOXE Transcription Factors Synergism Transcription Factors - genetics Transcription Factors - metabolism transcriptional regulation Upstream
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