Tumour-suppression activity of the proapoptotic regulator Par4

The proapoptotic protein encoded by Par4 (prostate apoptosis response 4) has been implicated in tumour suppression, particularly in the prostate. We report here that Par4 ‐null mice are prone to develop tumours, both spontaneously and on carcinogenic treatment. The endometrium and prostate of Par4 ‐...

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Veröffentlicht in:	EMBO reports 2005-06, Vol.6 (6), p.577-583
Hauptverfasser:	García-Cao, Isabel, Duran, Angeles, Collado, Manuel, Carrascosa, Maria J, Martín-Caballero, Juan, Flores, Juana M, Diaz-Meco, Maria T, Moscat, Jorge, Serrano, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals apoptosis Apoptosis - physiology Butylhydroxybutylnitrosamine - toxicity Endometrial Neoplasms - chemically induced Endometrial Neoplasms - metabolism endometrium Estradiol - toxicity Female Histological Techniques Immunoblotting Lesions Male Mice Mice, Mutant Strains Par4 Phenotype prostate Prostatic Neoplasms - chemically induced Prostatic Neoplasms - metabolism protein kinase C Proteins - metabolism Receptors, Thrombin - metabolism Scientific Report Testosterone - toxicity Tumors tumour suppression Urinary Bladder Neoplasms - chemically induced Urinary Bladder Neoplasms - metabolism X-Linked Inhibitor of Apoptosis Protein
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