Differential foetal development of the O‐ and N‐demethylation of codeine and dextromethorphan in man

1. Codeine and dextromethorphan were N‐demethylated in human foetal liver microsomes at high rates which were close to the activities in adult livers. In contrast, foetal liver microsomes did not catalyze the O‐demethylation of these drugs at mid‐gestation. 2. The metabolic data were in accordance w...

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Veröffentlicht in:	British journal of clinical pharmacology 1991-09, Vol.32 (3), p.295-302
Hauptverfasser:	Ladona, MG, Lindstrom, B, Thyr, C, Dun‐Ren, P, Rane, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal Blotting, Western Chromatography, High Pressure Liquid Codeine - metabolism Cytochrome P-450 CYP2D6 Cytochrome P-450 Enzyme System - metabolism Dehydroepiandrosterone - pharmacology Dextromethorphan - metabolism Embryonic and Fetal Development Humans Methylation Microsomes, Liver - enzymology Microsomes, Liver - metabolism Midazolam - pharmacology Mixed Function Oxygenases - metabolism
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