Lack of a pharmacokinetic interaction between phenobarbitone and gabapentin
Twelve subjects received a single oral dose (300 mg) of gabapentin and serial blood and urine samples were collected for drug measurements. Oral phenobarbitone (30‐90 mg/day) was then administered to steady‐ state, and the gabapentin single dose study was repeated on day 42. Gabapentin was administe...
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| Veröffentlicht in: | British journal of clinical pharmacology 1991-02, Vol.31 (2), p.171-174 |
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| container_title | British journal of clinical pharmacology |
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| creator | Hooper, WD Kavanagh, MC Herkes, GK Eadie, MJ |
| description | Twelve subjects received a single oral dose (300 mg) of gabapentin and serial blood and urine samples were collected for drug measurements. Oral phenobarbitone (30‐90 mg/day) was then administered to steady‐ state, and the gabapentin single dose study was repeated on day 42. Gabapentin was administered from days 49 to 52 to achieved steady‐ state, and further blood and urine samples were collected for drug measurements. Trough plasma phenobarbitone concentrations were monitored at frequent intervals. No statistically significant differences were observed in gabapentin Cmax, tmax, AUC, t1/2 or urinary drug recovery following single doses of gabapentin alone or combined with phenobarbitone. Phenobarbitone did not alter the disposition of gabapentin at steady state. Mean trough steady‐state phenobarbitone concentrations were not significantly affected by concomitant gabapentin administration. |
| doi_str_mv | 10.1111/j.1365-2125.1991.tb05507.x |
| format | Article |
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Oral phenobarbitone (30‐90 mg/day) was then administered to steady‐ state, and the gabapentin single dose study was repeated on day 42. Gabapentin was administered from days 49 to 52 to achieved steady‐ state, and further blood and urine samples were collected for drug measurements. Trough plasma phenobarbitone concentrations were monitored at frequent intervals. No statistically significant differences were observed in gabapentin Cmax, tmax, AUC, t1/2 or urinary drug recovery following single doses of gabapentin alone or combined with phenobarbitone. Phenobarbitone did not alter the disposition of gabapentin at steady state. Mean trough steady‐state phenobarbitone concentrations were not significantly affected by concomitant gabapentin administration.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.1991.tb05507.x</identifier><identifier>PMID: 2049232</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acetates - adverse effects ; Acetates - pharmacokinetics ; Acetates - pharmacology ; Adolescent ; Adult ; Amines ; Anticonvulsants - pharmacokinetics ; Anticonvulsants - pharmacology ; Cyclohexanecarboxylic Acids ; Drug Interactions ; Female ; Gabapentin ; gamma-Aminobutyric Acid ; Humans ; Male ; Phenobarbital - pharmacokinetics ; Phenobarbital - pharmacology</subject><ispartof>British journal of clinical pharmacology, 1991-02, Vol.31 (2), p.171-174</ispartof><rights>1991 The British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4777-17f8d2d996a095d5c90cd7284d9baacc8ce8c52b515ab56e36c9241d1d1e20193</citedby><cites>FETCH-LOGICAL-c4777-17f8d2d996a095d5c90cd7284d9baacc8ce8c52b515ab56e36c9241d1d1e20193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2049232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hooper, WD</creatorcontrib><creatorcontrib>Kavanagh, MC</creatorcontrib><creatorcontrib>Herkes, GK</creatorcontrib><creatorcontrib>Eadie, MJ</creatorcontrib><title>Lack of a pharmacokinetic interaction between phenobarbitone and gabapentin</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>Twelve subjects received a single oral dose (300 mg) of gabapentin and serial blood and urine samples were collected for drug measurements. Oral phenobarbitone (30‐90 mg/day) was then administered to steady‐ state, and the gabapentin single dose study was repeated on day 42. Gabapentin was administered from days 49 to 52 to achieved steady‐ state, and further blood and urine samples were collected for drug measurements. Trough plasma phenobarbitone concentrations were monitored at frequent intervals. No statistically significant differences were observed in gabapentin Cmax, tmax, AUC, t1/2 or urinary drug recovery following single doses of gabapentin alone or combined with phenobarbitone. Phenobarbitone did not alter the disposition of gabapentin at steady state. Mean trough steady‐state phenobarbitone concentrations were not significantly affected by concomitant gabapentin administration.</description><subject>Acetates - adverse effects</subject><subject>Acetates - pharmacokinetics</subject><subject>Acetates - pharmacology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Amines</subject><subject>Anticonvulsants - pharmacokinetics</subject><subject>Anticonvulsants - pharmacology</subject><subject>Cyclohexanecarboxylic Acids</subject><subject>Drug Interactions</subject><subject>Female</subject><subject>Gabapentin</subject><subject>gamma-Aminobutyric Acid</subject><subject>Humans</subject><subject>Male</subject><subject>Phenobarbital - pharmacokinetics</subject><subject>Phenobarbital - pharmacology</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFtLw0AQhRdRaq3-BCH4nriXbJL1QdHiDQv6oM_L7CXt1nY3JNG2_96ElqKPzjzMwJlzBj6ELghOSFeX84SwjMeUUJ4QIUjSKsw5zpP1ARrupUM0xAxnMaecHKOTppljTBjJ-AANKE4FZXSIXiagP6NQRhBVM6iXoMOn87Z1OnK-tTXo1gUfKduurPXdjfVBQa1cG7yNwJtoCgoq61vnT9FRCYvGnu3mCH083L-Pn-LJ6-Pz-HYS6zTP85jkZWGoESIDLLjhWmBtclqkRigArQttC82p4oSD4pllmRY0JaZrSzERbISut7nVl1pao7vnNSxkVbsl1BsZwMm_inczOQ3fskNTsIJ3AVfbAF2HpqltufcSLHvCct7fctljlD1huSMs1535_Pf3vXWHtNNvtvrKLezmH8nybvzWb-wHmMSN_w</recordid><startdate>199102</startdate><enddate>199102</enddate><creator>Hooper, WD</creator><creator>Kavanagh, MC</creator><creator>Herkes, GK</creator><creator>Eadie, MJ</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>199102</creationdate><title>Lack of a pharmacokinetic interaction between phenobarbitone and gabapentin</title><author>Hooper, WD ; Kavanagh, MC ; Herkes, GK ; Eadie, MJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4777-17f8d2d996a095d5c90cd7284d9baacc8ce8c52b515ab56e36c9241d1d1e20193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Acetates - adverse effects</topic><topic>Acetates - pharmacokinetics</topic><topic>Acetates - pharmacology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Amines</topic><topic>Anticonvulsants - pharmacokinetics</topic><topic>Anticonvulsants - pharmacology</topic><topic>Cyclohexanecarboxylic Acids</topic><topic>Drug Interactions</topic><topic>Female</topic><topic>Gabapentin</topic><topic>gamma-Aminobutyric Acid</topic><topic>Humans</topic><topic>Male</topic><topic>Phenobarbital - pharmacokinetics</topic><topic>Phenobarbital - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hooper, WD</creatorcontrib><creatorcontrib>Kavanagh, MC</creatorcontrib><creatorcontrib>Herkes, GK</creatorcontrib><creatorcontrib>Eadie, MJ</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hooper, WD</au><au>Kavanagh, MC</au><au>Herkes, GK</au><au>Eadie, MJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of a pharmacokinetic interaction between phenobarbitone and gabapentin</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1991-02</date><risdate>1991</risdate><volume>31</volume><issue>2</issue><spage>171</spage><epage>174</epage><pages>171-174</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><abstract>Twelve subjects received a single oral dose (300 mg) of gabapentin and serial blood and urine samples were collected for drug measurements. Oral phenobarbitone (30‐90 mg/day) was then administered to steady‐ state, and the gabapentin single dose study was repeated on day 42. Gabapentin was administered from days 49 to 52 to achieved steady‐ state, and further blood and urine samples were collected for drug measurements. Trough plasma phenobarbitone concentrations were monitored at frequent intervals. No statistically significant differences were observed in gabapentin Cmax, tmax, AUC, t1/2 or urinary drug recovery following single doses of gabapentin alone or combined with phenobarbitone. Phenobarbitone did not alter the disposition of gabapentin at steady state. Mean trough steady‐state phenobarbitone concentrations were not significantly affected by concomitant gabapentin administration.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2049232</pmid><doi>10.1111/j.1365-2125.1991.tb05507.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 1991-02, Vol.31 (2), p.171-174 |
| issn | 0306-5251 1365-2125 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acetates - adverse effects Acetates - pharmacokinetics Acetates - pharmacology Adolescent Adult Amines Anticonvulsants - pharmacokinetics Anticonvulsants - pharmacology Cyclohexanecarboxylic Acids Drug Interactions Female Gabapentin gamma-Aminobutyric Acid Humans Male Phenobarbital - pharmacokinetics Phenobarbital - pharmacology |
| title | Lack of a pharmacokinetic interaction between phenobarbitone and gabapentin |
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