Pharmacokinetics of CGP 6140 (amocarzine) after oral administration of single 100‐1600 mg doses to patients with onchocerciasis

The concentrations of CGP 6140 [4‐nitro‐4′‐(N‐methyl‐ piperazinylthiocarbonylamido)‐diphenylamine] and of its N‐oxide metabolite, CGP 13,231, were measured in plasma and urine after single oral dose of 100‐1600 mg of CGP 6140 to 41 fasted Ghanaian patients with Onchocerca volvulus infections. The ab...

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