The excretion of zopiclone into breast milk
1. The excretion of zopiclone into breast milk was studied in 12 lactating women in the early postpartum period following the oral administration of a single zopiclone tablet (7.5 mg). 2. The milk/plasma AUC ratio of zopiclone was 0.51 +/− 0.09 (mean +/− s.d.). Individual mean milk/plasma concentrat...
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| Veröffentlicht in: | British journal of clinical pharmacology 1990-08, Vol.30 (2), p.267-271 |
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| creator | Matheson, I Sande, HA Gaillot, J |
| description | 1. The excretion of zopiclone into breast milk was studied in 12 lactating women in the early postpartum period following the oral administration of a single zopiclone tablet (7.5 mg). 2. The milk/plasma AUC ratio of zopiclone was 0.51 +/− 0.09 (mean +/− s.d.). Individual mean milk/plasma concentration ratios of zopiclone showed significant interindividual variation (range 0.41‐0.70). 3. A comparison of pharmacokinetic parameters in the postpartum women with those reported previously in non‐pregnant women, showed significantly higher Cmax values in the lactating mothers; tmax occurred later in milk than in maternal plasma. 4. Assuming a daily milk intake of 0.15 l kg‐1 and 100% absorption the average infant dose of zopiclone in milk would be 1.4% of the weight adjusted dose ingested by the mother. |
| doi_str_mv | 10.1111/j.1365-2125.1990.tb03774.x |
| format | Article |
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The excretion of zopiclone into breast milk was studied in 12 lactating women in the early postpartum period following the oral administration of a single zopiclone tablet (7.5 mg). 2. The milk/plasma AUC ratio of zopiclone was 0.51 +/− 0.09 (mean +/− s.d.). Individual mean milk/plasma concentration ratios of zopiclone showed significant interindividual variation (range 0.41‐0.70). 3. A comparison of pharmacokinetic parameters in the postpartum women with those reported previously in non‐pregnant women, showed significantly higher Cmax values in the lactating mothers; tmax occurred later in milk than in maternal plasma. 4. Assuming a daily milk intake of 0.15 l kg‐1 and 100% absorption the average infant dose of zopiclone in milk would be 1.4% of the weight adjusted dose ingested by the mother.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.1990.tb03774.x</identifier><identifier>PMID: 2206788</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Azabicyclo Compounds ; Female ; Humans ; Hypnotics and Sedatives - blood ; Hypnotics and Sedatives - pharmacokinetics ; Milk, Human - metabolism ; Piperazines - blood ; Piperazines - pharmacokinetics ; Postpartum Period - metabolism</subject><ispartof>British journal of clinical pharmacology, 1990-08, Vol.30 (2), p.267-271</ispartof><rights>1990 The British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5104-da93a7b186c9db7754aae1ef26d49b9b1ff8b04c6190f1d40eb8195b622f95fc3</citedby><cites>FETCH-LOGICAL-c5104-da93a7b186c9db7754aae1ef26d49b9b1ff8b04c6190f1d40eb8195b622f95fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2206788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matheson, I</creatorcontrib><creatorcontrib>Sande, HA</creatorcontrib><creatorcontrib>Gaillot, J</creatorcontrib><title>The excretion of zopiclone into breast milk</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>1. The excretion of zopiclone into breast milk was studied in 12 lactating women in the early postpartum period following the oral administration of a single zopiclone tablet (7.5 mg). 2. The milk/plasma AUC ratio of zopiclone was 0.51 +/− 0.09 (mean +/− s.d.). Individual mean milk/plasma concentration ratios of zopiclone showed significant interindividual variation (range 0.41‐0.70). 3. A comparison of pharmacokinetic parameters in the postpartum women with those reported previously in non‐pregnant women, showed significantly higher Cmax values in the lactating mothers; tmax occurred later in milk than in maternal plasma. 4. Assuming a daily milk intake of 0.15 l kg‐1 and 100% absorption the average infant dose of zopiclone in milk would be 1.4% of the weight adjusted dose ingested by the mother.</description><subject>Azabicyclo Compounds</subject><subject>Female</subject><subject>Humans</subject><subject>Hypnotics and Sedatives - blood</subject><subject>Hypnotics and Sedatives - pharmacokinetics</subject><subject>Milk, Human - metabolism</subject><subject>Piperazines - blood</subject><subject>Piperazines - pharmacokinetics</subject><subject>Postpartum Period - metabolism</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUU1LxDAQDaLo-vEThOJBBGnNJE3beFB08QsEPeg5JGmiWbvN2nR1119vyy6LXgTnMgPvzZuPh9AB4AS6OBklQDMWEyAsAc5x0ipM8zxNZmtosILW0QBTnMWMMNhC2yGMMAYKGdtEm4TgLC-KATp-ejWRmenGtM7XkbfRl584XfnaRK5ufaQaI0MbjV31tos2rKyC2VvmHfR8ffU0vI3vH27uhhf3sWaA07iUnMpcQZFpXqo8Z6mUBowlWZlyxRVYWyic6gw4tlCm2KgCOFMZIZYzq-kOOlvoTqZqbEpt6raRlZg0biybufDSid9I7V7Fi_8Q3ekFIXkncLgUaPz71IRWjF3Qpqpkbfw0iKJ7BOaEd8SjP4lQ0JxCmnLaUU8XVN34EBpjV_sAFr0rYtTPZ6J_vehdEUtXxKxr3v950ap1aUOHny_wT1eZ-T-UxeXwsa_oNwf2nRk</recordid><startdate>199008</startdate><enddate>199008</enddate><creator>Matheson, I</creator><creator>Sande, HA</creator><creator>Gaillot, J</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199008</creationdate><title>The excretion of zopiclone into breast milk</title><author>Matheson, I ; Sande, HA ; Gaillot, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5104-da93a7b186c9db7754aae1ef26d49b9b1ff8b04c6190f1d40eb8195b622f95fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Azabicyclo Compounds</topic><topic>Female</topic><topic>Humans</topic><topic>Hypnotics and Sedatives - blood</topic><topic>Hypnotics and Sedatives - pharmacokinetics</topic><topic>Milk, Human - metabolism</topic><topic>Piperazines - blood</topic><topic>Piperazines - pharmacokinetics</topic><topic>Postpartum Period - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matheson, I</creatorcontrib><creatorcontrib>Sande, HA</creatorcontrib><creatorcontrib>Gaillot, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matheson, I</au><au>Sande, HA</au><au>Gaillot, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The excretion of zopiclone into breast milk</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1990-08</date><risdate>1990</risdate><volume>30</volume><issue>2</issue><spage>267</spage><epage>271</epage><pages>267-271</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><abstract>1. The excretion of zopiclone into breast milk was studied in 12 lactating women in the early postpartum period following the oral administration of a single zopiclone tablet (7.5 mg). 2. The milk/plasma AUC ratio of zopiclone was 0.51 +/− 0.09 (mean +/− s.d.). Individual mean milk/plasma concentration ratios of zopiclone showed significant interindividual variation (range 0.41‐0.70). 3. A comparison of pharmacokinetic parameters in the postpartum women with those reported previously in non‐pregnant women, showed significantly higher Cmax values in the lactating mothers; tmax occurred later in milk than in maternal plasma. 4. Assuming a daily milk intake of 0.15 l kg‐1 and 100% absorption the average infant dose of zopiclone in milk would be 1.4% of the weight adjusted dose ingested by the mother.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2206788</pmid><doi>10.1111/j.1365-2125.1990.tb03774.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 1990-08, Vol.30 (2), p.267-271 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Azabicyclo Compounds Female Humans Hypnotics and Sedatives - blood Hypnotics and Sedatives - pharmacokinetics Milk, Human - metabolism Piperazines - blood Piperazines - pharmacokinetics Postpartum Period - metabolism |
| title | The excretion of zopiclone into breast milk |
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