Statistical Signs of Synaptic Interaction in Neurons

Statistical Signs of Synaptic Interaction in Neurons

The influence of basic open-loop synaptic connections on the firing of simultaneously recorded neurons has been investigated with auto- and cross-correlation histograms, using experimental records and computer simulations. The basic connections examined were direct synaptic excitation, direct synapt...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biophysical journal 1970-09, Vol.10 (9), p.876-900
Hauptverfasser: Moore, George P., Segundo, Jose P., Perkel, Donald H., Levitan, Herbert
Format: Artikel
Sprache:eng
Schlagworte:
Computers
Mollusca
Neurons - physiology
Statistics as Topic
Synapses
Synaptic Transmission
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 900
container_issue 9
container_start_page 876
container_title Biophysical journal
container_volume 10
creator Moore, George P.
Segundo, Jose P.
Perkel, Donald H.
Levitan, Herbert
description The influence of basic open-loop synaptic connections on the firing of simultaneously recorded neurons has been investigated with auto- and cross-correlation histograms, using experimental records and computer simulations. The basic connections examined were direct synaptic excitation, direct synaptic inhibition, and shared synaptic input. Each type of synaptic connection produces certain characteristic features in the cross-correlogram depending on the properties of the synapse and statistical features in the firing pattern of each neuron. Thus, empirically derived cross-correlation measures can be interpreted in terms of the underlying physiological mechanisms. Their potential uses and limitations in the detection and identification of synaptic connections between neurons whose extracellularly recorded spike trains are available are discussed.
doi_str_mv 10.1016/S0006-3495(70)86341-X
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1367820</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S000634957086341X</els_id><sourcerecordid>80771726</sourcerecordid><originalsourceid>FETCH-LOGICAL-c580t-b77919100ff10a0891c2cb539f64c08a2ff965cd2f609f335062abd1bcef8a3f3</originalsourceid><addsrcrecordid>eNqFkE1LxDAQhoMouq7-BKEn0UN1krRJe1Fk8QtED6vgLaRpopFusibpgv_eurssevI0MO_HDA9CRxjOMGB2PgUAltOiLk84nFaMFjh_3UIjXBYkB6jYNhptLHtoP8YPAExKwLtot6CEkAJGqJgmmWxMVskum9o3FzNvsumXk_Nhl927pINUyXqXWZc96j54Fw_QjpFd1IfrOUYvN9fPk7v84en2fnL1kKuygpQ3nNe4xgDGYJBQ1VgR1ZS0NqxQUEliTM1K1RLDoDaUlsCIbFrcKG0qSQ0do4tV77xvZrpV2qUgOzEPdibDl_DSir-Ks-_izS8EpoxXBIaC43VB8J-9jknMbFS666TTvo-iAs4xJ2wwliujCj7GoM3mCAbxg1sscYsfloKDWOIWr0Pu6PeHm9Sa76BfrnQ9YFpYHURUVjulWxu0SqL19p8L38x8kEg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80771726</pqid></control><display><type>article</type><title>Statistical Signs of Synaptic Interaction in Neurons</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>Cell Press Free Archives</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Moore, George P. ; Segundo, Jose P. ; Perkel, Donald H. ; Levitan, Herbert</creator><creatorcontrib>Moore, George P. ; Segundo, Jose P. ; Perkel, Donald H. ; Levitan, Herbert</creatorcontrib><description>The influence of basic open-loop synaptic connections on the firing of simultaneously recorded neurons has been investigated with auto- and cross-correlation histograms, using experimental records and computer simulations. The basic connections examined were direct synaptic excitation, direct synaptic inhibition, and shared synaptic input. Each type of synaptic connection produces certain characteristic features in the cross-correlogram depending on the properties of the synapse and statistical features in the firing pattern of each neuron. Thus, empirically derived cross-correlation measures can be interpreted in terms of the underlying physiological mechanisms. Their potential uses and limitations in the detection and identification of synaptic connections between neurons whose extracellularly recorded spike trains are available are discussed.</description><identifier>ISSN: 0006-3495</identifier><identifier>EISSN: 1542-0086</identifier><identifier>DOI: 10.1016/S0006-3495(70)86341-X</identifier><identifier>PMID: 4322240</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Computers ; Mollusca ; Neurons - physiology ; Statistics as Topic ; Synapses ; Synaptic Transmission</subject><ispartof>Biophysical journal, 1970-09, Vol.10 (9), p.876-900</ispartof><rights>1970 The Biophysical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c580t-b77919100ff10a0891c2cb539f64c08a2ff965cd2f609f335062abd1bcef8a3f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1367820/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-3495(70)86341-X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3550,27924,27925,45995,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4322240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moore, George P.</creatorcontrib><creatorcontrib>Segundo, Jose P.</creatorcontrib><creatorcontrib>Perkel, Donald H.</creatorcontrib><creatorcontrib>Levitan, Herbert</creatorcontrib><title>Statistical Signs of Synaptic Interaction in Neurons</title><title>Biophysical journal</title><addtitle>Biophys J</addtitle><description>The influence of basic open-loop synaptic connections on the firing of simultaneously recorded neurons has been investigated with auto- and cross-correlation histograms, using experimental records and computer simulations. The basic connections examined were direct synaptic excitation, direct synaptic inhibition, and shared synaptic input. Each type of synaptic connection produces certain characteristic features in the cross-correlogram depending on the properties of the synapse and statistical features in the firing pattern of each neuron. Thus, empirically derived cross-correlation measures can be interpreted in terms of the underlying physiological mechanisms. Their potential uses and limitations in the detection and identification of synaptic connections between neurons whose extracellularly recorded spike trains are available are discussed.</description><subject>Computers</subject><subject>Mollusca</subject><subject>Neurons - physiology</subject><subject>Statistics as Topic</subject><subject>Synapses</subject><subject>Synaptic Transmission</subject><issn>0006-3495</issn><issn>1542-0086</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMouq7-BKEn0UN1krRJe1Fk8QtED6vgLaRpopFusibpgv_eurssevI0MO_HDA9CRxjOMGB2PgUAltOiLk84nFaMFjh_3UIjXBYkB6jYNhptLHtoP8YPAExKwLtot6CEkAJGqJgmmWxMVskum9o3FzNvsumXk_Nhl927pINUyXqXWZc96j54Fw_QjpFd1IfrOUYvN9fPk7v84en2fnL1kKuygpQ3nNe4xgDGYJBQ1VgR1ZS0NqxQUEliTM1K1RLDoDaUlsCIbFrcKG0qSQ0do4tV77xvZrpV2qUgOzEPdibDl_DSir-Ks-_izS8EpoxXBIaC43VB8J-9jknMbFS666TTvo-iAs4xJ2wwliujCj7GoM3mCAbxg1sscYsfloKDWOIWr0Pu6PeHm9Sa76BfrnQ9YFpYHURUVjulWxu0SqL19p8L38x8kEg</recordid><startdate>19700901</startdate><enddate>19700901</enddate><creator>Moore, George P.</creator><creator>Segundo, Jose P.</creator><creator>Perkel, Donald H.</creator><creator>Levitan, Herbert</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19700901</creationdate><title>Statistical Signs of Synaptic Interaction in Neurons</title><author>Moore, George P. ; Segundo, Jose P. ; Perkel, Donald H. ; Levitan, Herbert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-b77919100ff10a0891c2cb539f64c08a2ff965cd2f609f335062abd1bcef8a3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Computers</topic><topic>Mollusca</topic><topic>Neurons - physiology</topic><topic>Statistics as Topic</topic><topic>Synapses</topic><topic>Synaptic Transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moore, George P.</creatorcontrib><creatorcontrib>Segundo, Jose P.</creatorcontrib><creatorcontrib>Perkel, Donald H.</creatorcontrib><creatorcontrib>Levitan, Herbert</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biophysical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moore, George P.</au><au>Segundo, Jose P.</au><au>Perkel, Donald H.</au><au>Levitan, Herbert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Statistical Signs of Synaptic Interaction in Neurons</atitle><jtitle>Biophysical journal</jtitle><addtitle>Biophys J</addtitle><date>1970-09-01</date><risdate>1970</risdate><volume>10</volume><issue>9</issue><spage>876</spage><epage>900</epage><pages>876-900</pages><issn>0006-3495</issn><eissn>1542-0086</eissn><abstract>The influence of basic open-loop synaptic connections on the firing of simultaneously recorded neurons has been investigated with auto- and cross-correlation histograms, using experimental records and computer simulations. The basic connections examined were direct synaptic excitation, direct synaptic inhibition, and shared synaptic input. Each type of synaptic connection produces certain characteristic features in the cross-correlogram depending on the properties of the synapse and statistical features in the firing pattern of each neuron. Thus, empirically derived cross-correlation measures can be interpreted in terms of the underlying physiological mechanisms. Their potential uses and limitations in the detection and identification of synaptic connections between neurons whose extracellularly recorded spike trains are available are discussed.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4322240</pmid><doi>10.1016/S0006-3495(70)86341-X</doi><tpages>25</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0006-3495
ispartof Biophysical journal, 1970-09, Vol.10 (9), p.876-900
issn 0006-3495
1542-0086
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1367820
source MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects Computers
Mollusca
Neurons - physiology
Statistics as Topic
Synapses
Synaptic Transmission
title Statistical Signs of Synaptic Interaction in Neurons
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T12%3A20%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Statistical%20Signs%20of%20Synaptic%20Interaction%20in%20Neurons&rft.jtitle=Biophysical%20journal&rft.au=Moore,%20George%20P.&rft.date=1970-09-01&rft.volume=10&rft.issue=9&rft.spage=876&rft.epage=900&rft.pages=876-900&rft.issn=0006-3495&rft.eissn=1542-0086&rft_id=info:doi/10.1016/S0006-3495(70)86341-X&rft_dat=%3Cproquest_pubme%3E80771726%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80771726&rft_id=info:pmid/4322240&rft_els_id=S000634957086341X&rfr_iscdi=true