Three-Dimensional Visualization of FKBP12.6 Binding to an Open Conformation of Cardiac Ryanodine Receptor

The cardiac isoform of the ryanodine receptor (RyR2) from dog binds predominantly a 12.6-kDa isoform of the FK506-binding protein (FKBP12.6), whereas RyR2 from other species binds both FKBP12.6 and the closely related isoform FKBP12. The role played by FKBP12.6 in modulating calcium release by RyR2...

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Veröffentlicht in:	Biophysical journal 2006-01, Vol.90 (1), p.164-172
Hauptverfasser:	Sharma, Manjuli Rani, Jeyakumar, Loice H., Fleischer, Sidney, Wagenknecht, Terence
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biophysics - methods Blotting, Western Calcium Calcium - metabolism Cardiology Cell Membrane - metabolism Channels, Receptors, and Electrical Signaling Cryoelectron Microscopy Dogs Electrophoresis, Polyacrylamide Gel Image Processing, Computer-Assisted Imaging, Three-Dimensional Microscopy, Electron Microsomes - metabolism Models, Molecular Molecular Conformation Muscle, Skeletal - metabolism Muscular system Myocardium - metabolism Patch-Clamp Techniques Protein Binding Protein Conformation Protein Isoforms Protein Structure, Secondary Protein Structure, Tertiary Proteins Proteins - chemistry Recombinant Proteins - chemistry Ryanodine - chemistry Ryanodine Receptor Calcium Release Channel - chemistry Sarcoplasmic Reticulum - metabolism Tacrolimus Binding Proteins - chemistry Tacrolimus Binding Proteins - metabolism Time Factors X-Rays
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