Single-Molecule FRET Studies of Important Intermediates in the Nucleocapsid-Protein-Chaperoned Minus-Strand Transfer Step in HIV-1 Reverse Transcription

The minus-strand transfer step of HIV-1 reverse transcription is chaperoned by the nucleocapsid protein (NC), which has been shown to facilitate the annealing between the transactivation response element (TAR) RNA and complementary TAR DNA stem-loop structures. In this work, potential intermediates...

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Veröffentlicht in:	Biophysical journal 2005-11, Vol.89 (5), p.3470-3479
Hauptverfasser:	Liu, Hsiao-Wei, Cosa, Gonzalo, Landes, Christy F., Zeng, Yining, Kovaleski, Brandie J., Mullen, Daniel G., Barany, George, Musier-Forsyth, Karin, Barbara, Paul F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biochemistry Deoxyribonucleic acid DNA DNA - chemistry DNA, Complementary - metabolism Fluorescence Resonance Energy Transfer - methods HIV Long Terminal Repeat - genetics HIV Reverse Transcriptase - genetics HIV-1 - metabolism Human immunodeficiency virus 1 Kinetics Microscopy, Fluorescence Models, Biological Models, Chemical Molecular Chaperones Molecular Sequence Data Molecules Nucleic Acid Conformation Nucleocapsid Proteins - chemistry Oligonucleotides - chemistry Protein Binding Proteins Reverse Transcription RNA - chemistry RNA, Viral Spectroscopy, Imaging, Other Techniques Time Factors Virus Replication
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