A relation between the chain length of fatty acids and the slowing of gastric emptying
1. Test meals of solutions and suspensions of potassium and sodium salts of a series of saturated fatty acids, from C 2 to C 18 , were given to healthy subjects. 2. From the volume of these meals recovered after a fixed interval the relative effectiveness of the salts of the acids in slowing gastric...
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| Veröffentlicht in: | The Journal of physiology 1968-02, Vol.194 (2), p.327-336 |
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| container_title | The Journal of physiology |
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| creator | Hunt, J. N. Knox, M. T. |
| description | 1. Test meals of solutions and suspensions of potassium and sodium salts of a series of saturated fatty acids, from C 2 to C 18 , were given to healthy subjects.
2. From the volume of these meals recovered after a fixed interval the relative effectiveness of the salts of the acids in
slowing gastric emptying was assessed.
3. On a molar basis the salts of fatty acids from acetic up to decanoic were relatively ineffective in slowing gastric emptying.
4. The salts of fatty acids with 12-18 carbon atoms were much more effective than those with up to 10 carbon atoms. Myristate
was the most effective of the salts.
5. Buffering the test meals with 33 m M sodium citrate increased the effectiveness of the salts in slowing gastric emptying. |
| doi_str_mv | 10.1113/jphysiol.1968.sp008411 |
| format | Article |
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2. From the volume of these meals recovered after a fixed interval the relative effectiveness of the salts of the acids in
slowing gastric emptying was assessed.
3. On a molar basis the salts of fatty acids from acetic up to decanoic were relatively ineffective in slowing gastric emptying.
4. The salts of fatty acids with 12-18 carbon atoms were much more effective than those with up to 10 carbon atoms. Myristate
was the most effective of the salts.
5. Buffering the test meals with 33 m M sodium citrate increased the effectiveness of the salts in slowing gastric emptying.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1968.sp008411</identifier><identifier>PMID: 5639357</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Acetates - pharmacology ; Butyrates - pharmacology ; Caproates - pharmacology ; Citrates - pharmacology ; Duodenum - physiology ; Fatty Acids - pharmacology ; Humans ; Intestinal Mucosa - physiology ; Molecular Weight ; Palmitic Acids - pharmacology ; Potassium - pharmacology ; Propionates - pharmacology ; Sensory Receptor Cells ; Sodium - pharmacology ; Stearic Acids - pharmacology ; Stomach - physiology</subject><ispartof>The Journal of physiology, 1968-02, Vol.194 (2), p.327-336</ispartof><rights>1968 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5667-2501e889ba56436faa101ba185d81ac3631d1ca92e3d91c4d030404f142451c83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1365796/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1365796/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5639357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hunt, J. N.</creatorcontrib><creatorcontrib>Knox, M. T.</creatorcontrib><title>A relation between the chain length of fatty acids and the slowing of gastric emptying</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. Test meals of solutions and suspensions of potassium and sodium salts of a series of saturated fatty acids, from C 2 to C 18 , were given to healthy subjects.
2. From the volume of these meals recovered after a fixed interval the relative effectiveness of the salts of the acids in
slowing gastric emptying was assessed.
3. On a molar basis the salts of fatty acids from acetic up to decanoic were relatively ineffective in slowing gastric emptying.
4. The salts of fatty acids with 12-18 carbon atoms were much more effective than those with up to 10 carbon atoms. Myristate
was the most effective of the salts.
5. Buffering the test meals with 33 m M sodium citrate increased the effectiveness of the salts in slowing gastric emptying.</description><subject>Acetates - pharmacology</subject><subject>Butyrates - pharmacology</subject><subject>Caproates - pharmacology</subject><subject>Citrates - pharmacology</subject><subject>Duodenum - physiology</subject><subject>Fatty Acids - pharmacology</subject><subject>Humans</subject><subject>Intestinal Mucosa - physiology</subject><subject>Molecular Weight</subject><subject>Palmitic Acids - pharmacology</subject><subject>Potassium - pharmacology</subject><subject>Propionates - pharmacology</subject><subject>Sensory Receptor Cells</subject><subject>Sodium - pharmacology</subject><subject>Stearic Acids - pharmacology</subject><subject>Stomach - physiology</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1968</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EKtvCRwD5BKcsnthx7AtSW1H-qBIcClfL60wSV9k4xF5W-fYkZFvBjdNI8977zUiPkNfAtgDA390P7RR96LagpdrGgTElAJ6QDQips7LU_CnZMJbnGS8LeE7OY7xnDDjT-oycFZJrXpQb8uOSjtjZ5ENPd5iOiD1NLVLXWt_TDvsmtTTUtLYpTdQ6X0Vq--qPJ3bh6PtmkRsb0-gdxf2Qpnn3gjyrbRfx5WlekO83H-6uP2W3Xz9-vr68zVwhZZnlBQNUSu9sIQWXtbXAYGdBFZUC67jkUIGzOkdeaXCiYpwJJmoQuSjAKX5B3q_c4bDbY-WwT6PtzDD6vR0nE6w3_yq9b00Tfhngsii1nAFvToAx_DxgTGbvo8Ousz2GQzRKlFpxwWejXI1uDDGOWD8eAWaWRsxDI2ZpxDw0Mgdf_f3iY-xUwaxfrfrRdzj9J9Xcffm2LECLnOcL5O0KaX3THv2IZo3F4DymmaaFyc3i_A2r6q30</recordid><startdate>19680201</startdate><enddate>19680201</enddate><creator>Hunt, J. N.</creator><creator>Knox, M. T.</creator><general>The Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19680201</creationdate><title>A relation between the chain length of fatty acids and the slowing of gastric emptying</title><author>Hunt, J. N. ; Knox, M. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5667-2501e889ba56436faa101ba185d81ac3631d1ca92e3d91c4d030404f142451c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1968</creationdate><topic>Acetates - pharmacology</topic><topic>Butyrates - pharmacology</topic><topic>Caproates - pharmacology</topic><topic>Citrates - pharmacology</topic><topic>Duodenum - physiology</topic><topic>Fatty Acids - pharmacology</topic><topic>Humans</topic><topic>Intestinal Mucosa - physiology</topic><topic>Molecular Weight</topic><topic>Palmitic Acids - pharmacology</topic><topic>Potassium - pharmacology</topic><topic>Propionates - pharmacology</topic><topic>Sensory Receptor Cells</topic><topic>Sodium - pharmacology</topic><topic>Stearic Acids - pharmacology</topic><topic>Stomach - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hunt, J. N.</creatorcontrib><creatorcontrib>Knox, M. T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hunt, J. N.</au><au>Knox, M. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A relation between the chain length of fatty acids and the slowing of gastric emptying</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1968-02-01</date><risdate>1968</risdate><volume>194</volume><issue>2</issue><spage>327</spage><epage>336</epage><pages>327-336</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. Test meals of solutions and suspensions of potassium and sodium salts of a series of saturated fatty acids, from C 2 to C 18 , were given to healthy subjects.
2. From the volume of these meals recovered after a fixed interval the relative effectiveness of the salts of the acids in
slowing gastric emptying was assessed.
3. On a molar basis the salts of fatty acids from acetic up to decanoic were relatively ineffective in slowing gastric emptying.
4. The salts of fatty acids with 12-18 carbon atoms were much more effective than those with up to 10 carbon atoms. Myristate
was the most effective of the salts.
5. Buffering the test meals with 33 m M sodium citrate increased the effectiveness of the salts in slowing gastric emptying.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>5639357</pmid><doi>10.1113/jphysiol.1968.sp008411</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3751 |
| ispartof | The Journal of physiology, 1968-02, Vol.194 (2), p.327-336 |
| issn | 0022-3751 1469-7793 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1365796 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acetates - pharmacology Butyrates - pharmacology Caproates - pharmacology Citrates - pharmacology Duodenum - physiology Fatty Acids - pharmacology Humans Intestinal Mucosa - physiology Molecular Weight Palmitic Acids - pharmacology Potassium - pharmacology Propionates - pharmacology Sensory Receptor Cells Sodium - pharmacology Stearic Acids - pharmacology Stomach - physiology |
| title | A relation between the chain length of fatty acids and the slowing of gastric emptying |
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