Excitation of Mytilus smooth muscle
1. Membrane potentials and tension were recorded during nerve stimulation and direct stimulation of smooth muscle cells of the anterior byssus retractor muscle of Mytilus edulis L. 2. The resting potential averaged 65 mV (range 55-72 mV). 3. Junction potentials reached 25 mV and decayed to one half...
Gespeichert in:
| Veröffentlicht in: | The Journal of physiology 1967-10, Vol.192 (3), p.857-868 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 868 |
|---|---|
| container_issue | 3 |
| container_start_page | 857 |
| container_title | The Journal of physiology |
| container_volume | 192 |
| creator | Twarog, Betty M. |
| description | 1. Membrane potentials and tension were recorded during nerve stimulation and direct stimulation of smooth muscle cells of
the anterior byssus retractor muscle of Mytilus edulis L.
2. The resting potential averaged 65 mV (range 55-72 mV).
3. Junction potentials reached 25 mV and decayed to one half maximum amplitude in 500 msec. Spatial summation and facilitation
of junction potentials were observed.
4. Action potentials, 50 msec in duration and up to 50 mV in amplitude were fired at a membrane potential of 35-40 mV. No
overshoot was observed.
5. Contraction in response to neural stimulation was associated with spike discharge. Measurement of tension and depolarization
in muscle bundles at high K + indicated that tension is only produced at membrane potentials similar to those achieved by spike discharge.
6. Blocking of junction potentials, spike discharge and contraction by methantheline, an acetylcholine antagonist, supports
the hypothesis that the muscle is excited by cholinergic nerves. However, evidence of a presynaptic action of methantheline
complicates this argument. |
| doi_str_mv | 10.1113/jphysiol.1967.sp008336 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1365547</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>84579204</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5007-a460ad090add38c4442a049c083dcb5168a81aebeeee00d1d856059e25718d23</originalsourceid><addsrcrecordid>eNqNkF1PwyAYhYnRzDn9CZolJnrV-VKghRsTXeZXZvRi94RRtrK0Y5bW2X9vm25G7-QCEs45Dy8HoQsMI4wxuVlt0tpbl42wiOKR3wBwQqID1Mc0EkEcC3KI-gBhGJCY4WN04v0KABMQood6lHBCGeujy8mXtqUqrVsP3WL4Wpc2q_zQ586V6TCvvM7MKTpaqMybs905QLOHyWz8FEzfHp_Hd9NAM4A4UDQClYBotoRwTSkNFVChm8ESPWc44opjZeamWQAJTjiLgAkTshjzJCQDdNthN9U8N4k267JQmdwUNldFLZ2y8q-ytqlcuk-JScQYjRvA1Q5QuI_K-FLm1muTZWptXOUlpywWIdDGGHVGXTjvC7P4eQSDbNuV-3Zl267ct9sEz3-P-BPb1dno952-tZmp_0mVs5f39gKLkHDWfuO6g6R2mW5tYWQX805bUzY0EUoiW-c3AO-cJQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>84579204</pqid></control><display><type>article</type><title>Excitation of Mytilus smooth muscle</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Twarog, Betty M.</creator><creatorcontrib>Twarog, Betty M.</creatorcontrib><description>1. Membrane potentials and tension were recorded during nerve stimulation and direct stimulation of smooth muscle cells of
the anterior byssus retractor muscle of Mytilus edulis L.
2. The resting potential averaged 65 mV (range 55-72 mV).
3. Junction potentials reached 25 mV and decayed to one half maximum amplitude in 500 msec. Spatial summation and facilitation
of junction potentials were observed.
4. Action potentials, 50 msec in duration and up to 50 mV in amplitude were fired at a membrane potential of 35-40 mV. No
overshoot was observed.
5. Contraction in response to neural stimulation was associated with spike discharge. Measurement of tension and depolarization
in muscle bundles at high K + indicated that tension is only produced at membrane potentials similar to those achieved by spike discharge.
6. Blocking of junction potentials, spike discharge and contraction by methantheline, an acetylcholine antagonist, supports
the hypothesis that the muscle is excited by cholinergic nerves. However, evidence of a presynaptic action of methantheline
complicates this argument.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1967.sp008336</identifier><identifier>PMID: 4383455</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Action Potentials ; Animals ; In Vitro Techniques ; Membrane Potentials ; Mollusca ; Muscle Contraction - drug effects ; Muscle Contraction - physiology ; Muscle, Smooth - drug effects ; Muscle, Smooth - physiology ; Neuromuscular Junction - physiology ; Parasympathetic Nervous System - physiology ; Potassium - pharmacology ; Quaternary Ammonium Compounds - pharmacology</subject><ispartof>The Journal of physiology, 1967-10, Vol.192 (3), p.857-868</ispartof><rights>1967 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5007-a460ad090add38c4442a049c083dcb5168a81aebeeee00d1d856059e25718d23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1365547/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1365547/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4383455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Twarog, Betty M.</creatorcontrib><title>Excitation of Mytilus smooth muscle</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. Membrane potentials and tension were recorded during nerve stimulation and direct stimulation of smooth muscle cells of
the anterior byssus retractor muscle of Mytilus edulis L.
2. The resting potential averaged 65 mV (range 55-72 mV).
3. Junction potentials reached 25 mV and decayed to one half maximum amplitude in 500 msec. Spatial summation and facilitation
of junction potentials were observed.
4. Action potentials, 50 msec in duration and up to 50 mV in amplitude were fired at a membrane potential of 35-40 mV. No
overshoot was observed.
5. Contraction in response to neural stimulation was associated with spike discharge. Measurement of tension and depolarization
in muscle bundles at high K + indicated that tension is only produced at membrane potentials similar to those achieved by spike discharge.
6. Blocking of junction potentials, spike discharge and contraction by methantheline, an acetylcholine antagonist, supports
the hypothesis that the muscle is excited by cholinergic nerves. However, evidence of a presynaptic action of methantheline
complicates this argument.</description><subject>Action Potentials</subject><subject>Animals</subject><subject>In Vitro Techniques</subject><subject>Membrane Potentials</subject><subject>Mollusca</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle Contraction - physiology</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - physiology</subject><subject>Neuromuscular Junction - physiology</subject><subject>Parasympathetic Nervous System - physiology</subject><subject>Potassium - pharmacology</subject><subject>Quaternary Ammonium Compounds - pharmacology</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1PwyAYhYnRzDn9CZolJnrV-VKghRsTXeZXZvRi94RRtrK0Y5bW2X9vm25G7-QCEs45Dy8HoQsMI4wxuVlt0tpbl42wiOKR3wBwQqID1Mc0EkEcC3KI-gBhGJCY4WN04v0KABMQood6lHBCGeujy8mXtqUqrVsP3WL4Wpc2q_zQ586V6TCvvM7MKTpaqMybs905QLOHyWz8FEzfHp_Hd9NAM4A4UDQClYBotoRwTSkNFVChm8ESPWc44opjZeamWQAJTjiLgAkTshjzJCQDdNthN9U8N4k267JQmdwUNldFLZ2y8q-ytqlcuk-JScQYjRvA1Q5QuI_K-FLm1muTZWptXOUlpywWIdDGGHVGXTjvC7P4eQSDbNuV-3Zl267ct9sEz3-P-BPb1dno952-tZmp_0mVs5f39gKLkHDWfuO6g6R2mW5tYWQX805bUzY0EUoiW-c3AO-cJQ</recordid><startdate>19671001</startdate><enddate>19671001</enddate><creator>Twarog, Betty M.</creator><general>The Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19671001</creationdate><title>Excitation of Mytilus smooth muscle</title><author>Twarog, Betty M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5007-a460ad090add38c4442a049c083dcb5168a81aebeeee00d1d856059e25718d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Action Potentials</topic><topic>Animals</topic><topic>In Vitro Techniques</topic><topic>Membrane Potentials</topic><topic>Mollusca</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle Contraction - physiology</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - physiology</topic><topic>Neuromuscular Junction - physiology</topic><topic>Parasympathetic Nervous System - physiology</topic><topic>Potassium - pharmacology</topic><topic>Quaternary Ammonium Compounds - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Twarog, Betty M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Twarog, Betty M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excitation of Mytilus smooth muscle</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1967-10-01</date><risdate>1967</risdate><volume>192</volume><issue>3</issue><spage>857</spage><epage>868</epage><pages>857-868</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. Membrane potentials and tension were recorded during nerve stimulation and direct stimulation of smooth muscle cells of
the anterior byssus retractor muscle of Mytilus edulis L.
2. The resting potential averaged 65 mV (range 55-72 mV).
3. Junction potentials reached 25 mV and decayed to one half maximum amplitude in 500 msec. Spatial summation and facilitation
of junction potentials were observed.
4. Action potentials, 50 msec in duration and up to 50 mV in amplitude were fired at a membrane potential of 35-40 mV. No
overshoot was observed.
5. Contraction in response to neural stimulation was associated with spike discharge. Measurement of tension and depolarization
in muscle bundles at high K + indicated that tension is only produced at membrane potentials similar to those achieved by spike discharge.
6. Blocking of junction potentials, spike discharge and contraction by methantheline, an acetylcholine antagonist, supports
the hypothesis that the muscle is excited by cholinergic nerves. However, evidence of a presynaptic action of methantheline
complicates this argument.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>4383455</pmid><doi>10.1113/jphysiol.1967.sp008336</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3751 |
| ispartof | The Journal of physiology, 1967-10, Vol.192 (3), p.857-868 |
| issn | 0022-3751 1469-7793 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1365547 |
| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Action Potentials Animals In Vitro Techniques Membrane Potentials Mollusca Muscle Contraction - drug effects Muscle Contraction - physiology Muscle, Smooth - drug effects Muscle, Smooth - physiology Neuromuscular Junction - physiology Parasympathetic Nervous System - physiology Potassium - pharmacology Quaternary Ammonium Compounds - pharmacology |
| title | Excitation of Mytilus smooth muscle |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T15%3A14%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Excitation%20of%20Mytilus%20smooth%20muscle&rft.jtitle=The%20Journal%20of%20physiology&rft.au=Twarog,%20Betty%20M.&rft.date=1967-10-01&rft.volume=192&rft.issue=3&rft.spage=857&rft.epage=868&rft.pages=857-868&rft.issn=0022-3751&rft.eissn=1469-7793&rft_id=info:doi/10.1113/jphysiol.1967.sp008336&rft_dat=%3Cproquest_pubme%3E84579204%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=84579204&rft_id=info:pmid/4383455&rfr_iscdi=true |