Effect of multiple doses of losartan on the pharmacokinetics of single doses of digoxin in healthy volunteers

1. Losartan (DuP 753, MK‐954) is a novel, potent and highly selective AT1 angiotensin II receptor antagonist. The effect of multiple oral doses of losartan on digoxin pharmacokinetics was evaluated in healthy male subjects. 2. In a double‐blind and randomized fashion, subjects received 50 mg losarta...

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