The effect of meloxicam on the pharmacokinetics of beta‐acetyl‐digoxin
The influence of multiple‐dose administration of meloxicam on the pharmacokinetics of oral beta‐acetyl‐digoxin was studied in 12 healthy male volunteers in a randomized double‐blind two‐way crossover study. The primary endpoint, Cminss, was within the accepted range for bioequivalence, as were Cmaxs...
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| Veröffentlicht in: | British journal of clinical pharmacology 1995-11, Vol.40 (5), p.486-488 |
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| container_end_page | 488 |
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| container_issue | 5 |
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| container_title | British journal of clinical pharmacology |
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| creator | Degner, FL Heinzel, G. Narjes, H. Turck, D. |
| description | The influence of multiple‐dose administration of meloxicam on the pharmacokinetics of oral beta‐acetyl‐digoxin was studied in 12 healthy male volunteers in a randomized double‐blind two‐way crossover study. The primary endpoint, Cminss, was within the accepted range for bioequivalence, as were Cmaxss and AUCss. The 90% confidence interval and the point estimator of 98.7 for Cminss were within the equivalence range of 0.8‐1.25. MRT and tmax were also unchanged, while the elimination rate constant was decreased slightly by 12%, which is of no therapeutic relevance. It is concluded that co‐treatment with meloxicam has no effect on the pharmacokinetics of oral digoxin. |
| doi_str_mv | 10.1111/j.1365-2125.1995.tb05794.x |
| format | Article |
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The primary endpoint, Cminss, was within the accepted range for bioequivalence, as were Cmaxss and AUCss. The 90% confidence interval and the point estimator of 98.7 for Cminss were within the equivalence range of 0.8‐1.25. MRT and tmax were also unchanged, while the elimination rate constant was decreased slightly by 12%, which is of no therapeutic relevance. It is concluded that co‐treatment with meloxicam has no effect on the pharmacokinetics of oral digoxin.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.1995.tb05794.x</identifier><identifier>PMID: 8703654</identifier><identifier>CODEN: BCPHBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Acetyldigoxins - pharmacokinetics ; Adult ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Biological and medical sciences ; Cardiotonic agents ; Cardiovascular system ; Drug Interactions ; Half-Life ; Humans ; Male ; Medical sciences ; Meloxicam ; Metabolic Clearance Rate ; Pharmacology. 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The primary endpoint, Cminss, was within the accepted range for bioequivalence, as were Cmaxss and AUCss. The 90% confidence interval and the point estimator of 98.7 for Cminss were within the equivalence range of 0.8‐1.25. MRT and tmax were also unchanged, while the elimination rate constant was decreased slightly by 12%, which is of no therapeutic relevance. It is concluded that co‐treatment with meloxicam has no effect on the pharmacokinetics of oral digoxin.</description><subject>Acetyldigoxins - pharmacokinetics</subject><subject>Adult</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cardiotonic agents</subject><subject>Cardiovascular system</subject><subject>Drug Interactions</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meloxicam</subject><subject>Metabolic Clearance Rate</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Thiazines - pharmacology</topic><topic>Thiazoles - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Degner, FL</creatorcontrib><creatorcontrib>Heinzel, G.</creatorcontrib><creatorcontrib>Narjes, H.</creatorcontrib><creatorcontrib>Turck, D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Degner, FL</au><au>Heinzel, G.</au><au>Narjes, H.</au><au>Turck, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of meloxicam on the pharmacokinetics of beta‐acetyl‐digoxin</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1995-11</date><risdate>1995</risdate><volume>40</volume><issue>5</issue><spage>486</spage><epage>488</epage><pages>486-488</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><coden>BCPHBM</coden><abstract>The influence of multiple‐dose administration of meloxicam on the pharmacokinetics of oral beta‐acetyl‐digoxin was studied in 12 healthy male volunteers in a randomized double‐blind two‐way crossover study. The primary endpoint, Cminss, was within the accepted range for bioequivalence, as were Cmaxss and AUCss. The 90% confidence interval and the point estimator of 98.7 for Cminss were within the equivalence range of 0.8‐1.25. MRT and tmax were also unchanged, while the elimination rate constant was decreased slightly by 12%, which is of no therapeutic relevance. It is concluded that co‐treatment with meloxicam has no effect on the pharmacokinetics of oral digoxin.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>8703654</pmid><doi>10.1111/j.1365-2125.1995.tb05794.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-5251 |
| ispartof | British journal of clinical pharmacology, 1995-11, Vol.40 (5), p.486-488 |
| issn | 0306-5251 1365-2125 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1365196 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Acetyldigoxins - pharmacokinetics Adult Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Cardiotonic agents Cardiovascular system Drug Interactions Half-Life Humans Male Medical sciences Meloxicam Metabolic Clearance Rate Pharmacology. Drug treatments Thiazines - pharmacology Thiazoles - pharmacology |
| title | The effect of meloxicam on the pharmacokinetics of beta‐acetyl‐digoxin |
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