The effect of meloxicam on the pharmacokinetics of beta‐acetyl‐digoxin

The influence of multiple‐dose administration of meloxicam on the pharmacokinetics of oral beta‐acetyl‐digoxin was studied in 12 healthy male volunteers in a randomized double‐blind two‐way crossover study. The primary endpoint, Cminss, was within the accepted range for bioequivalence, as were Cmaxss and AUCss. The 90% confidence interval and the point estimator of 98.7 for Cminss were within the equivalence range of 0.8‐1.25. MRT and tmax were also unchanged, while the elimination rate constant was decreased slightly by 12%, which is of no therapeutic relevance. It is concluded that co‐treatment with meloxicam has no effect on the pharmacokinetics of oral digoxin.