Stereoselective disposition of ibuprofen enantiomers in human cerebrospinal fluid

Since both (R)‐ and (S)‐enantiomers of ibuprofen may act on the central nervous system, we investigated their plasma and cerebrospinal fluid (CSF) concentrations in 46 patients with nerve‐root compression pain requiring a lumbar puncture. Each patient received an oral dose of 800 mg rac‐ibuprofen. A...

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Veröffentlicht in:	British journal of clinical pharmacology 1995-09, Vol.40 (3), p.266-269
Hauptverfasser:	Bannwarth, B., Lapicque, F., Pehourcq, F., Gillet, P., Schaeverbeke, T., Laborde, C., Dehais, J., Gaucher, A., Netter, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Female Humans Ibuprofen - blood Ibuprofen - cerebrospinal fluid Ibuprofen - pharmacokinetics Male Middle Aged Pain Spinal Puncture Stereoisomerism Time Factors
Online-Zugang:	Volltext
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