Cefpiramide kinetics and plasma protein binding in cholestasis

Cefpiramide is a new parenteral cephalosporin mainly excreted in the bile. Eight patients with cholestasis and 11 healthy subjects received a single 1 g i.v. dose. Cefpiramide concentrations in plasma and urine were measured by h.p.l.c. and plasma binding was determined by ultrafiltration. Total cle...

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Veröffentlicht in:	British journal of clinical pharmacology 1994-03, Vol.37 (3), p.295-297
Hauptverfasser:	Demontes‐Mainard, F, Vincon, G, Labat, L, Amouretti, M, Necciari, J, Kieffer, G, Bannwarth, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Blood Proteins - metabolism Cephalosporins - administration & dosage Cephalosporins - blood Cephalosporins - pharmacokinetics Cephalosporins - urine Cholestasis - metabolism Chromatography, High Pressure Liquid Female Humans Injections, Intravenous Liver Function Tests Male Medical sciences Middle Aged Pharmacology. Drug treatments Protein Binding
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