The effects of age on the pharmacokinetics and pharmacodynamics of single oral doses of benazepril and enalapril
1. Eighteen healthy, normotensive subjects (nine young and nine elderly) participated in a double‐blind, 3‐way, crossover study to compare aspects of the pharmacokinetics and pharmacodynamics of single oral doses of 10 mg benazepril, 10 mg enalapril and placebo. 2. The hypotensive effect was similar...
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| Veröffentlicht in: | British journal of clinical pharmacology 1993-09, Vol.36 (3), p.205-209 |
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| creator | Macdonald, NJ Sioufi, A Howie, CA Wade, JR Elliott, HL |
| description | 1. Eighteen healthy, normotensive subjects (nine young and nine elderly) participated in a double‐blind, 3‐way, crossover study to compare aspects of the pharmacokinetics and pharmacodynamics of single oral doses of 10 mg benazepril, 10 mg enalapril and placebo. 2. The hypotensive effect was similar after both drugs but the absolute reductions were greater in the elderly who had higher initial levels of blood pressure. 3. The AUCs for both benazeprilat and enalaprilat were higher in the elderly but by a significantly greater amount for enalaprilat (+ 113% vs 40%; P < 0.01). 4. The AUCs for both drugs tended to be highest in subjects with the lowest creatinine clearance. 5. The changes in kinetics and dynamics observed in the elderly after benazepril are qualitatively similar to those with other ACE inhibitors. The clinical significance of the quantitative differences requires further investigation. |
| doi_str_mv | 10.1111/j.1365-2125.1993.tb04218.x |
| format | Article |
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Eighteen healthy, normotensive subjects (nine young and nine elderly) participated in a double‐blind, 3‐way, crossover study to compare aspects of the pharmacokinetics and pharmacodynamics of single oral doses of 10 mg benazepril, 10 mg enalapril and placebo. 2. The hypotensive effect was similar after both drugs but the absolute reductions were greater in the elderly who had higher initial levels of blood pressure. 3. The AUCs for both benazeprilat and enalaprilat were higher in the elderly but by a significantly greater amount for enalaprilat (+ 113% vs 40%; P < 0.01). 4. The AUCs for both drugs tended to be highest in subjects with the lowest creatinine clearance. 5. The changes in kinetics and dynamics observed in the elderly after benazepril are qualitatively similar to those with other ACE inhibitors. The clinical significance of the quantitative differences requires further investigation.</description><identifier>ISSN: 0306-5251</identifier><identifier>EISSN: 1365-2125</identifier><identifier>DOI: 10.1111/j.1365-2125.1993.tb04218.x</identifier><identifier>PMID: 9114905</identifier><identifier>CODEN: BCPHBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Oral ; Adolescent ; Age ; Aged ; Aging - metabolism ; Angiotensin-Converting Enzyme Inhibitors - administration & dosage ; Angiotensin-Converting Enzyme Inhibitors - adverse effects ; Angiotensin-Converting Enzyme Inhibitors - pharmacokinetics ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Antihypertensive Agents - administration & dosage ; Antihypertensive Agents - adverse effects ; Antihypertensive Agents - pharmacokinetics ; Antihypertensive Agents - pharmacology ; Benzazepines - administration & dosage ; Benzazepines - adverse effects ; Benzazepines - pharmacokinetics ; Benzazepines - pharmacology ; Biological and medical sciences ; Blood pressure ; Blood Pressure - drug effects ; Blood Proteins - metabolism ; Cardiovascular system ; Clinical trials ; Creatinine ; Cross-Over Studies ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drugs ; Enalapril - administration & dosage ; Enalapril - pharmacokinetics ; Enalapril - pharmacology ; Female ; Geriatrics ; Humans ; Kinetics ; Male ; Medical sciences ; Miscellaneous ; Peptidyl-Dipeptidase A - blood ; Pharmacodynamics ; Pharmacokinetics ; Pharmacology. Drug treatments ; Protein Binding</subject><ispartof>British journal of clinical pharmacology, 1993-09, Vol.36 (3), p.205-209</ispartof><rights>1993 The British Pharmacological Society</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6058-4b615f7355a09602a9b35ac4f4179a6eeb2398e4072ea18792f22ae7192871ea3</citedby><cites>FETCH-LOGICAL-c6058-4b615f7355a09602a9b35ac4f4179a6eeb2398e4072ea18792f22ae7192871ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3747913$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9114905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Macdonald, NJ</creatorcontrib><creatorcontrib>Sioufi, A</creatorcontrib><creatorcontrib>Howie, CA</creatorcontrib><creatorcontrib>Wade, JR</creatorcontrib><creatorcontrib>Elliott, HL</creatorcontrib><title>The effects of age on the pharmacokinetics and pharmacodynamics of single oral doses of benazepril and enalapril</title><title>British journal of clinical pharmacology</title><addtitle>Br J Clin Pharmacol</addtitle><description>1. Eighteen healthy, normotensive subjects (nine young and nine elderly) participated in a double‐blind, 3‐way, crossover study to compare aspects of the pharmacokinetics and pharmacodynamics of single oral doses of 10 mg benazepril, 10 mg enalapril and placebo. 2. The hypotensive effect was similar after both drugs but the absolute reductions were greater in the elderly who had higher initial levels of blood pressure. 3. The AUCs for both benazeprilat and enalaprilat were higher in the elderly but by a significantly greater amount for enalaprilat (+ 113% vs 40%; P < 0.01). 4. The AUCs for both drugs tended to be highest in subjects with the lowest creatinine clearance. 5. The changes in kinetics and dynamics observed in the elderly after benazepril are qualitatively similar to those with other ACE inhibitors. The clinical significance of the quantitative differences requires further investigation.</description><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Age</subject><subject>Aged</subject><subject>Aging - metabolism</subject><subject>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</subject><subject>Angiotensin-Converting Enzyme Inhibitors - adverse effects</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacokinetics</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Antihypertensive Agents - administration & dosage</subject><subject>Antihypertensive Agents - adverse effects</subject><subject>Antihypertensive Agents - pharmacokinetics</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Benzazepines - administration & dosage</subject><subject>Benzazepines - adverse effects</subject><subject>Benzazepines - pharmacokinetics</subject><subject>Benzazepines - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Proteins - metabolism</subject><subject>Cardiovascular system</subject><subject>Clinical trials</subject><subject>Creatinine</subject><subject>Cross-Over Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Drugs</subject><subject>Enalapril - administration & dosage</subject><subject>Enalapril - pharmacokinetics</subject><subject>Enalapril - pharmacology</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Peptidyl-Dipeptidase A - blood</subject><subject>Pharmacodynamics</subject><subject>Pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein Binding</subject><issn>0306-5251</issn><issn>1365-2125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUU2P0zAUtBBo6S78BKQIceCS4GfHScwBBNXyIa0Eh-VsvbjPbUrilDiFLb8eZxtFcMQX2_NmxiMPY8-BZxDXq30GslCpAKEy0FpmY81zAVV294CtltFDtuKSF6kSCh6zyxD2nIOEQl2wCw2Qa65W7HC7o4ScIzuGpHcJbinpfTJG9LDDoUPbf288jY0NCfrNAm5OHrsJjJrQ-G0bZQO2yaYPdA_W5PE3HYamvdfFW4vT7Ql75LAN9HTer9i3D9e360_pzZePn9fvblJbcFWleV2AcqVUCrkuuEBdS4U2dzmUGguiWkhdUc5LQQhVqYUTAqkELaoSCOUVe3P2PRzrjjaW_BjzmRihw-FkemzMvxPf7My2_2ni_-WF1NHg5Www9D-OFEbTNcFS26Kn_hgMcFFxKXNQkfr6TLVDH8JAbnkGuJkaM_vJVpmpFjM1ZubGzF0UP_s76CKdK4rzF_Mcg8XWDehtExaaLPNSg4y0t2far6al038EMO_XX6eT_AOj27SQ</recordid><startdate>199309</startdate><enddate>199309</enddate><creator>Macdonald, NJ</creator><creator>Sioufi, A</creator><creator>Howie, CA</creator><creator>Wade, JR</creator><creator>Elliott, HL</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>199309</creationdate><title>The effects of age on the pharmacokinetics and pharmacodynamics of single oral doses of benazepril and enalapril</title><author>Macdonald, NJ ; Sioufi, A ; Howie, CA ; Wade, JR ; Elliott, HL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6058-4b615f7355a09602a9b35ac4f4179a6eeb2398e4072ea18792f22ae7192871ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Age</topic><topic>Aged</topic><topic>Aging - metabolism</topic><topic>Angiotensin-Converting Enzyme Inhibitors - administration & dosage</topic><topic>Angiotensin-Converting Enzyme Inhibitors - adverse effects</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacokinetics</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Antihypertensive Agents - administration & dosage</topic><topic>Antihypertensive Agents - adverse effects</topic><topic>Antihypertensive Agents - pharmacokinetics</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Benzazepines - administration & dosage</topic><topic>Benzazepines - adverse effects</topic><topic>Benzazepines - pharmacokinetics</topic><topic>Benzazepines - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Proteins - metabolism</topic><topic>Cardiovascular system</topic><topic>Clinical trials</topic><topic>Creatinine</topic><topic>Cross-Over Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Drugs</topic><topic>Enalapril - administration & dosage</topic><topic>Enalapril - pharmacokinetics</topic><topic>Enalapril - pharmacology</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Peptidyl-Dipeptidase A - blood</topic><topic>Pharmacodynamics</topic><topic>Pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Binding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Macdonald, NJ</creatorcontrib><creatorcontrib>Sioufi, A</creatorcontrib><creatorcontrib>Howie, CA</creatorcontrib><creatorcontrib>Wade, JR</creatorcontrib><creatorcontrib>Elliott, HL</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Macdonald, NJ</au><au>Sioufi, A</au><au>Howie, CA</au><au>Wade, JR</au><au>Elliott, HL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of age on the pharmacokinetics and pharmacodynamics of single oral doses of benazepril and enalapril</atitle><jtitle>British journal of clinical pharmacology</jtitle><addtitle>Br J Clin Pharmacol</addtitle><date>1993-09</date><risdate>1993</risdate><volume>36</volume><issue>3</issue><spage>205</spage><epage>209</epage><pages>205-209</pages><issn>0306-5251</issn><eissn>1365-2125</eissn><coden>BCPHBM</coden><abstract>1. Eighteen healthy, normotensive subjects (nine young and nine elderly) participated in a double‐blind, 3‐way, crossover study to compare aspects of the pharmacokinetics and pharmacodynamics of single oral doses of 10 mg benazepril, 10 mg enalapril and placebo. 2. The hypotensive effect was similar after both drugs but the absolute reductions were greater in the elderly who had higher initial levels of blood pressure. 3. The AUCs for both benazeprilat and enalaprilat were higher in the elderly but by a significantly greater amount for enalaprilat (+ 113% vs 40%; P < 0.01). 4. The AUCs for both drugs tended to be highest in subjects with the lowest creatinine clearance. 5. The changes in kinetics and dynamics observed in the elderly after benazepril are qualitatively similar to those with other ACE inhibitors. The clinical significance of the quantitative differences requires further investigation.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9114905</pmid><doi>10.1111/j.1365-2125.1993.tb04218.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0306-5251 1365-2125 |
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| subjects | Administration, Oral Adolescent Age Aged Aging - metabolism Angiotensin-Converting Enzyme Inhibitors - administration & dosage Angiotensin-Converting Enzyme Inhibitors - adverse effects Angiotensin-Converting Enzyme Inhibitors - pharmacokinetics Angiotensin-Converting Enzyme Inhibitors - pharmacology Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Antihypertensive Agents - pharmacokinetics Antihypertensive Agents - pharmacology Benzazepines - administration & dosage Benzazepines - adverse effects Benzazepines - pharmacokinetics Benzazepines - pharmacology Biological and medical sciences Blood pressure Blood Pressure - drug effects Blood Proteins - metabolism Cardiovascular system Clinical trials Creatinine Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Drugs Enalapril - administration & dosage Enalapril - pharmacokinetics Enalapril - pharmacology Female Geriatrics Humans Kinetics Male Medical sciences Miscellaneous Peptidyl-Dipeptidase A - blood Pharmacodynamics Pharmacokinetics Pharmacology. Drug treatments Protein Binding |
| title | The effects of age on the pharmacokinetics and pharmacodynamics of single oral doses of benazepril and enalapril |
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