Vitamin D differentially regulates B7.1 and B7.2 expression on human peripheral blood monocytes

The hormonal active form of vitamin D3, 1,25‐dihydroxyvitamin D3 (1,25(OH)2D3), inhibits (through an unknown mechanism) the ability of monocytes/macrophages to induce T‐cell activation. For T cells to be optimally activated, recognition of antigen/major histocompatibility complexes (MHC) by the T‐ce...

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Veröffentlicht in:	Immunology 1998-10, Vol.95 (2), p.272-277
Hauptverfasser:	Clavreul, A, D'hellencourt, C L, Montero-Menei, C, Potron, G, Couez, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen Presentation - drug effects Antigens, CD - metabolism B7-1 Antigen - metabolism B7-2 Antigen Calcitriol - analogs & derivatives Calcitriol - pharmacology CD4 Antigens - metabolism Cytokines - pharmacology Dose-Response Relationship, Drug Flow Cytometry Histocompatibility Antigens Class I - metabolism Histocompatibility Antigens Class II - metabolism Human health and pathology Humans Immunosuppressive Agents - pharmacology Life Sciences Lipopolysaccharide Receptors - metabolism Lipopolysaccharides - pharmacology Membrane Glycoproteins - metabolism Monocytes - drug effects Monocytes - immunology Time Factors
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