Biochemical and Physiological Properties of Rhodopsin Regenerated with 11-cis-6-Ring- and 7-Ring-retinals

Phototransduction is initiated by the photoisomerization of rhodopsin (Rho) chromophore 11- cis -retinylidene to all- trans- retinylidene. Here, using Rho regenerated with retinal analogs with different ring sizes, which prevent isomerization around the C 11 =C 12 double bond, the activation mechani...

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Veröffentlicht in:	The Journal of biological chemistry 2002-11, Vol.277 (44), p.42315-42324
Hauptverfasser:	Kuksa, Vladimir, Bartl, Franz, Maeda, Tadao, Jang, Geeng-Fu, Ritter, Eglof, Heck, Martin, Preston Van Hooser, J, Liang, Yan, Filipek, Sławomir, Gelb, Michael H, Hofmann, Klaus Peter, Palczewski, Krzysztof
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Hydrogen-Ion Concentration Mice Phosphorylation Protein Conformation Retinal Degeneration Retinaldehyde - metabolism Rhodopsin - biosynthesis Rhodopsin - chemistry Spectroscopy, Fourier Transform Infrared
Online-Zugang:	Volltext
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