Conditional telomerase induction causes proliferation of hair follicle stem cells
TERT, the protein component of telomerase, serves to maintain telomere function through the de novo addition of telomere repeats to chromosome ends, and is reactivated in 90% of human cancers. In normal tissues, TERT is expressed in stem cells and in progenitor cells, but its role in these compartme...
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| Veröffentlicht in: | Nature 2005-08, Vol.436 (7053), p.1048-1052 |
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| creator | Oro, Anthony E Cheung, Peggie Artandi, Maja K Artandi, Steven E Wang, Estee Lee, Eunice Gilison, Daniel Tennen, Ruth I Sarin, Kavita Y |
| description | TERT, the protein component of telomerase, serves to maintain telomere function through the de novo addition of telomere repeats to chromosome ends, and is reactivated in 90% of human cancers. In normal tissues, TERT is expressed in stem cells and in progenitor cells, but its role in these compartments is not fully understood. Here we show that conditional transgenic induction of TERT in mouse skin epithelium causes a rapid transition from telogen (the resting phase of the hair follicle cycle) to anagen (the active phase), thereby facilitating robust hair growth. TERT overexpression promotes this developmental transition by causing proliferation of quiescent, multipotent stem cells in the hair follicle bulge region. This new function for TERT does not require the telomerase RNA component, which encodes the template for telomere addition, and therefore operates through a mechanism independent of its activity in synthesizing telomere repeats. These data indicate that, in addition to its established role in extending telomeres, TERT can promote proliferation of resting stem cells through a non-canonical pathway. |
| doi_str_mv | 10.1038/nature03836 |
| format | Article |
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These data indicate that, in addition to its established role in extending telomeres, TERT can promote proliferation of resting stem cells through a non-canonical pathway.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/nature03836</identifier><identifier>PMID: 16107853</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biological and medical sciences ; Bromodeoxyuridine - metabolism ; Cancer ; Cell Proliferation ; Chromosomes ; DNA-Binding Proteins - deficiency ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Enzyme Induction ; Enzymes ; Fundamental and applied biological sciences. Psychology ; Hair ; Hair Follicle - cytology ; Hair Follicle - enzymology ; Humanities and Social Sciences ; letter ; Mice ; Mice, Transgenic ; multidisciplinary ; RNA - genetics ; Science ; Science (multidisciplinary) ; Stem cells ; Stem Cells - cytology ; Stem Cells - enzymology ; Telomerase - deficiency ; Telomerase - genetics ; Telomerase - metabolism ; Transgenes - genetics ; Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue</subject><ispartof>Nature, 2005-08, Vol.436 (7053), p.1048-1052</ispartof><rights>Springer Nature Limited 2005</rights><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 18, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c734t-4383d861ec56b9404a4d4f1187643e2370910199fc3b3b3dc4f03f29da32b71b3</citedby><cites>FETCH-LOGICAL-c734t-4383d861ec56b9404a4d4f1187643e2370910199fc3b3b3dc4f03f29da32b71b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nature03836$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nature03836$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,2725,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17033540$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16107853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oro, Anthony E</creatorcontrib><creatorcontrib>Cheung, Peggie</creatorcontrib><creatorcontrib>Artandi, Maja K</creatorcontrib><creatorcontrib>Artandi, Steven E</creatorcontrib><creatorcontrib>Wang, Estee</creatorcontrib><creatorcontrib>Lee, Eunice</creatorcontrib><creatorcontrib>Gilison, Daniel</creatorcontrib><creatorcontrib>Tennen, Ruth I</creatorcontrib><creatorcontrib>Sarin, Kavita Y</creatorcontrib><title>Conditional telomerase induction causes proliferation of hair follicle stem cells</title><title>Nature</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>TERT, the protein component of telomerase, serves to maintain telomere function through the de novo addition of telomere repeats to chromosome ends, and is reactivated in 90% of human cancers. 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In normal tissues, TERT is expressed in stem cells and in progenitor cells, but its role in these compartments is not fully understood. Here we show that conditional transgenic induction of TERT in mouse skin epithelium causes a rapid transition from telogen (the resting phase of the hair follicle cycle) to anagen (the active phase), thereby facilitating robust hair growth. TERT overexpression promotes this developmental transition by causing proliferation of quiescent, multipotent stem cells in the hair follicle bulge region. This new function for TERT does not require the telomerase RNA component, which encodes the template for telomere addition, and therefore operates through a mechanism independent of its activity in synthesizing telomere repeats. 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| subjects | Animals Biological and medical sciences Bromodeoxyuridine - metabolism Cancer Cell Proliferation Chromosomes DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enzyme Induction Enzymes Fundamental and applied biological sciences. Psychology Hair Hair Follicle - cytology Hair Follicle - enzymology Humanities and Social Sciences letter Mice Mice, Transgenic multidisciplinary RNA - genetics Science Science (multidisciplinary) Stem cells Stem Cells - cytology Stem Cells - enzymology Telomerase - deficiency Telomerase - genetics Telomerase - metabolism Transgenes - genetics Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue |
| title | Conditional telomerase induction causes proliferation of hair follicle stem cells |
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