Multimers of the fibroblast growth factor (FGF)-FGF receptor-saccharide complex are formed on long oligomers of heparin

The minimal signalling unit for tyrosine kinase receptors is two protomers dimerized by one or more ligands. However, it is clear that maximal signalling requires the formation of larger complexes of many receptors at discrete foci on the cell surface. The biological interactions that lead to this a...

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Veröffentlicht in:	Biochemical journal 2006-02, Vol.393 (Pt 3), p.741-748
Hauptverfasser:	Harmer, Nicholas J, Robinson, Christopher J, Adam, Lucy E, Ilag, Leopold L, Robinson, Carol V, Gallagher, John T, Blundell, Tom L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Fibroblast Growth Factor 1 - chemistry Fibroblast Growth Factor 1 - metabolism Heparin - chemistry Heparin - metabolism Heparitin Sulfate - chemistry Heparitin Sulfate - metabolism Molecular Weight Multiprotein Complexes - chemistry Multiprotein Complexes - metabolism Protein Binding Receptor, Fibroblast Growth Factor, Type 2 - chemistry Receptor, Fibroblast Growth Factor, Type 2 - metabolism Swine Ultracentrifugation
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